Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Carbohydr Polym. 2021 Apr 1;257:117631. doi: 10.1016/j.carbpol.2021.117631. Epub 2021 Jan 11.
The coaxial electrospinning for producing core-shell nanofibers due to control the release profile of drug by the shell layer has been developed. N-carboxymethyl chitosan (CMC)-polyvinyl alcohol (core)/poly(ε-caprolactone) (PCL) (shell) nanofibers were produced via coaxial electrospinning. Doxorubicin (DOX) and nickel ferrite nanoparticles were incorporated into the nanofibers for controlled release of DOX against MCF-7 breast cancer. The minimum CMC/PCL fiber diameter was found to be 300 nm by optimizing of three variables including voltage to distance ratio (1.5-2.5 kV/cm), CMC concentration (4-6 wt.%) and PCL concentration (8-12 wt.%). The synthesized core-shell fibers were characterized using FTIR, XRD, SEM, and TEM analysis. The extended release and controlled release of DOX from core-shell nanofibers were achieved under physiological pH without external magnetic field (EMF) and acidic pH with EMF during 25 and 7 days, respectively. The maximum cytotoxicity of MCF-7 breast cancer cells was about 83 % using CMC/PCL/nickel ferrite 10 % nanofibers and EMF.
同轴静电纺丝可通过控制壳层来控制药物的释放特性，从而制备核壳结构纳米纤维。通过同轴静电纺丝制备了 N-羧甲基壳聚糖（CMC）-聚乙烯醇（芯）/聚（ε-己内酯）（PCL）（壳）纳米纤维。将阿霉素（DOX）和四氧化三铁纳米颗粒掺入纳米纤维中，以实现 DOX 的控释，用于 MCF-7 乳腺癌的治疗。通过优化三个变量（电压与距离比（1.5-2.5 kV/cm）、CMC 浓度（4-6wt.%）和 PCL 浓度（8-12wt.%）），发现最小的 CMC/PCL 纤维直径为 300nm。采用傅里叶变换红外光谱（FTIR）、X 射线衍射（XRD）、扫描电子显微镜（SEM）和透射电子显微镜（TEM）对合成的核壳纤维进行了表征。在没有外加磁场（EMF）的生理 pH 条件下和有 EMF 的酸性 pH 条件下，DOX 分别实现了 25 天和 7 天的缓释和控释。使用 CMC/PCL/四氧化三铁 10%纳米纤维和 EMF，MCF-7 乳腺癌细胞的最大细胞毒性约为 83%。
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