Deng Lijuan, Xu Yifan, Sun Caixia, Yun Baofeng, Sun Qiao, Zhao Chongjun, Li Zhen
Key Laboratory for Ultrafine Materials of Ministry of Education, Shanghai Key Laboratory of Advanced Polymeric Materials, School of Material Science and Engineering, East China University of Science and Technology, Shanghai 200237, China; Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China.
Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China.
Sci Bull (Beijing). 2018 Jul 30;63(14):917-924. doi: 10.1016/j.scib.2018.05.022. Epub 2018 May 25.
Black phosphorus (BP) nanomaterials have attracted extensive attention due to their unique physical, chemical, and biological properties. In this study, small BP nanoparticles were synthesized and modified with dextran and poly(ethyleneimine) for functionalization with folic acid and cyanine 7. The functionalized BP nanoparticles exhibit excellent biocompatibility, stability, and near infrared optical properties for targeted imaging of tumors through photoacoustic imaging and near-infrared fluorescence imaging. They also display high photothermal conversion efficiency for photothermal therapy of cancer. This work demonstrates the potential of functionalized small BP nanoparticles as an emerging nanotheranostic agent for the diagnosis and treatment of cancer.
黑磷（BP）纳米材料因其独特的物理、化学和生物学性质而受到广泛关注。在本研究中，合成了小尺寸的BP纳米颗粒，并用葡聚糖和聚乙烯亚胺进行修饰，以实现叶酸和花菁7的功能化。功能化的BP纳米颗粒表现出优异的生物相容性、稳定性以及近红外光学特性，可通过光声成像和近红外荧光成像对肿瘤进行靶向成像。它们还具有高光热转换效率，可用于癌症的光热治疗。这项工作证明了功能化的小尺寸BP纳米颗粒作为一种新兴的纳米诊疗剂用于癌症诊断和治疗的潜力。
