Smith Luke S, Haidari Hanif, Amsalu Anteneh, Howarth Gordon S, Bryant Saffron J, Walia Sumeet, Elbourne Aaron, Kopecki Zlatko
School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371, Australia.
Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia.
Int J Mol Sci. 2024 Nov 28;25(23):12824. doi: 10.3390/ijms252312824.
Black phosphorus (BP), a two-dimensional material, has gathered significant attention over the last decade, primarily due to its unique physiochemical properties and potential role in various biomedical applications. This review provides an in-depth overview of the synthesis, nanomaterial properties, interactions, and biomedical uses of BP, with a particular focus on wound management. The structure, synthesis methods, and stability of BP are discussed, highlighting the high degree of nanomaterial biocompatibility and cytotoxicity. The antimicrobial properties of BP, including mechanisms of action and preclinical studies to date, are examined, emphasizing the effectiveness of BP against various clinical pathogens relevant to wound management. Additionally, the versatility of BP in biomedical implementations is highlighted through utilization in drug delivery, imaging, and photothermal therapy, with a focus on scalability and reproducibility with outlined future perspectives. Despite identified challenges for translation in clinical uses, BP nanomaterial has significant potential as a versatile platform in biomedical applications, especially in wound management.
黑磷（BP）作为一种二维材料，在过去十年中备受关注，这主要归功于其独特的物理化学性质以及在各种生物医学应用中的潜在作用。本综述深入概述了黑磷的合成、纳米材料特性、相互作用及生物医学用途，特别关注伤口处理。文中讨论了黑磷的结构、合成方法和稳定性，强调了其高度的纳米材料生物相容性和细胞毒性。研究了黑磷的抗菌特性，包括作用机制和迄今为止的临床前研究，强调了黑磷对与伤口处理相关的各种临床病原体的有效性。此外，通过在药物递送、成像和光热治疗中的应用，突出了黑磷在生物医学应用中的多功能性，重点关注可扩展性和可重复性，并概述了未来前景。尽管在临床应用转化方面存在已确定的挑战，但黑磷纳米材料作为生物医学应用中的多功能平台具有巨大潜力，尤其是在伤口处理方面。
