吗啡通过中枢作用减少迷走神经刺激引起的胃酸分泌。

Morphine reduces vagal-stimulated gastric acid secretion through a central action.

作者信息

Ho M M, Dai S, Ogle C W

机构信息

Department of Pharmacology, Faculty of Medicine, University of Hong Kong.

出版信息

Eur J Pharmacol. 1987 Jul 23;139(3):251-7. doi: 10.1016/0014-2999(87)90581-4.

DOI:10.1016/0014-2999(87)90581-4

PMID:3666004

Abstract

The influence of morphine on gastric acid secretion stimulated by 2-deoxy-D-glucose or electrical vagal stimulation was studied in anaesthetised rats with perfused stomachs. It was found that changes in gastric acid output induced by electrical vagal stimulation were not noticeably affected, whereas those evoked by 2-deoxy-D-glucose were significantly suppressed by morphine pretreatment. The depressant effect of the opiate on the acid secretion stimulated by 2-deoxy-D-glucose was abolished by naloxone pretreatment. It is suggested that morphine inhibits vagal-stimulated gastric acid secretion in rats by acting predominantly on opioid receptors in the central nervous system.

摘要

在麻醉状态下具有灌注胃的大鼠中，研究了吗啡对由2-脱氧-D-葡萄糖或电迷走神经刺激所激发的胃酸分泌的影响。结果发现，电迷走神经刺激所引起的胃酸分泌变化未受到明显影响，而2-脱氧-D-葡萄糖所诱发的胃酸分泌变化则被吗啡预处理显著抑制。纳洛酮预处理消除了阿片类药物对2-脱氧-D-葡萄糖刺激的胃酸分泌的抑制作用。提示吗啡主要通过作用于中枢神经系统的阿片受体来抑制大鼠迷走神经刺激的胃酸分泌。