Maeda-Hagiwara M, Watanabe K
Eur J Pharmacol. 1983 May 20;90(1):11-7. doi: 10.1016/0014-2999(83)90208-x.
The influence of bromocriptine on the secretagogue-induced gastric acid secretion was examined in rats. The drug inhibited the gastric acid secretion centrally stimulated by 2-deoxy-D-glucose (2DG) in anesthetized or conscious rats. Apomorphine also prevented 2DG-induced acid secretion in anesthetized rats but not in conscious rats. Neither bromocriptine nor apomorphine significantly influenced the acid secretion induced peripherally by electrical vagus stimulation or gastrin. The antisecretory effect of bromocriptine was reversed by dopamine antagonists in anesthetized or conscious rats, but not by apomorphine in anesthetized rats. The results suggest that in rats, the antisecretory effect of bromocriptine on 2DG-stimulated acid secretion is partly due to its central dopamine agonistic action, but that of apomorphine may be due to dopaminergic plus other mechanisms.
在大鼠中研究了溴隐亭对促分泌剂诱导的胃酸分泌的影响。该药物抑制了麻醉或清醒大鼠中由2-脱氧-D-葡萄糖（2DG）中枢刺激引起的胃酸分泌。阿扑吗啡也可防止麻醉大鼠中2DG诱导的胃酸分泌，但对清醒大鼠无效。溴隐亭和阿扑吗啡均未显著影响电刺激迷走神经或胃泌素外周诱导的胃酸分泌。在麻醉或清醒大鼠中，多巴胺拮抗剂可逆转溴隐亭的抗分泌作用，但在麻醉大鼠中阿扑吗啡不能逆转。结果表明，在大鼠中，溴隐亭对2DG刺激的胃酸分泌的抗分泌作用部分归因于其中枢多巴胺激动作用，而阿扑吗啡的抗分泌作用可能归因于多巴胺能及其他机制。
