Límanová Z, Neuwirtova R, Smejkal V
3rd Medical Clinic, Faculty of General Medicine, Charles University Hospital, Prague, Czechoslovakia.
Exp Clin Endocrinol. 1987 Aug;90(1):113-9. doi: 10.1055/s-0029-1210680.
Eighteen cases of patients with malignant lymphoma of the thyroid are analyzed. Patients were treated by irradiation and/or chemotherapy and in 9 cases the operation of the thyroid was realized. Two patients of operated group and two patients of non-operated group died after 1-365 days due to malignant lymphoma. The mean follow up of living patients is 66.8 months. In 5 cases, the coincidence of malignant lymphoma and lymphocytic thyroiditis was proved. The diagnosis of malignant lymphoma of the thyroid in all cases but one was based on cytology gained from fine needle biopsy and then confirmed in most cases by histology. We advise to use fine needle biopsy as a simple and safe method in all solitary nodules of the thyroid of uncertain origin and urgent fine needle biopsy in cases of fast growing mass on the neck. Fine needle biopsy reliably differentiates between primary thyroid carcinoma, anaplastic carcinoma and malignant lymphoma of the thyroid. Difficulties can arise in differential diagnosis between malignant lymphoma and lymphocytic thyroiditis.
分析了18例甲状腺恶性淋巴瘤患者。患者接受了放疗和/或化疗，9例患者进行了甲状腺手术。手术组和非手术组各有2例患者在1 - 365天后因恶性淋巴瘤死亡。存活患者的平均随访时间为66.8个月。5例患者证实存在恶性淋巴瘤与淋巴细胞性甲状腺炎并存。除1例病例外，所有甲状腺恶性淋巴瘤的诊断均基于细针穿刺活检获得的细胞学结果，大多数病例随后经组织学证实。我们建议，对于所有起源不明的甲状腺孤立性结节，采用细针穿刺活检作为一种简单安全的方法；对于颈部快速生长的肿块，应紧急进行细针穿刺活检。细针穿刺活检能够可靠地区分原发性甲状腺癌、未分化癌和甲状腺恶性淋巴瘤。在恶性淋巴瘤与淋巴细胞性甲状腺炎的鉴别诊断中可能会出现困难。
