Matsuda M, Sone H, Koyama H, Ishiguro S
Department of Clinical Cytology, Surgery, and Pathology, Center for Adult Diseases, Osaka, Japan.
Diagn Cytopathol. 1987 Sep;3(3):244-9. doi: 10.1002/dc.2840030314.
Our experience with fine-needle aspiration cytology in five cases of malignant lymphoma of the thyroid is reported. Only one case was correctly diagnosed as malignant lymphoma from the original cytologic reports. Three cases were misdiagnosed as anaplastic carcinoma of small-cell type and two of these three cases were subsequently revised as malignant lymphoma after a second aspiration. The final case was misdiagnosed as chronic thyroiditis at both the first and second aspirations; following a third aspiration, 8 mo later, it was correctly diagnosed as malignant lymphoma. Cytological findings of malignant lymphoma are as follows: many malignant cells are distributed as isolated cells and show monotonous features. Malignant cells are slightly larger than normal lymphocytes. Sometimes cleaved cells or large nucleoli are visible. The differential diagnosis of cytologic findings of malignant lymphoma and the other thyroid diseases is discussed in detail.
本文报告了我们对5例甲状腺恶性淋巴瘤进行细针穿刺细胞学检查的经验。最初的细胞学报告中，只有1例被正确诊断为恶性淋巴瘤。3例被误诊为小细胞型间变性癌，其中2例在二次穿刺后被修正为恶性淋巴瘤。最后1例在首次和二次穿刺时均被误诊为慢性甲状腺炎；8个月后进行第三次穿刺，才被正确诊断为恶性淋巴瘤。恶性淋巴瘤的细胞学表现如下：许多恶性细胞呈单个细胞分布，具有单一特征。恶性细胞比正常淋巴细胞略大。有时可见核分裂细胞或大核仁。文中详细讨论了恶性淋巴瘤与其他甲状腺疾病细胞学表现的鉴别诊断。
