• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

亚得里亚海的 TTX 污染热点：起源与成因研究。

A Hotspot of TTX Contamination in the Adriatic Sea: Study on the Origin and Causative Factors.

机构信息

Istituto Zooprofilattico Sperimentale Umbria e Marche "Togo Rosati", Via G. Salvemini, 1, 06126 Perugia, Italy.

Centro di Referenza Nazionale per il Controllo Chimico e Microbiologico dei Molluschi Bivalvi Vivi, Istituto Zooprofilattico Sperimentale Umbria e Marche "Togo Rosati", Via Cupa di Posatora, 3, 60131 Ancona, Italy.

出版信息

Mar Drugs. 2022 Dec 22;21(1):8. doi: 10.3390/md21010008.

DOI:10.3390/md21010008
PMID:36662181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9866420/
Abstract

Tetrodotoxins (TTXs), the pufferfish venom traditionally associated with Indo-Pacific area, has been reported during last decades in ever wider range of marine organisms and ever more geographical areas, including shellfish in Europe. Wild mussels () grown in the Marche Region (N Adriatic Sea, Italy) were shown to be prone to TTX contamination during the warm season, with a suspected role of characterized by non-ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS)-encoding genes. This work aimed to deepen the knowledge about the toxin's origin and the way through which it accumulates in mussels. A two-year study (spring-summer 2020-2021) confirmed the recurrent presence of TTX (11-68 µg kg) in the official monitored natural mussel beds of the Conero Riviera. During 2021, a supplementary nonroutine monitoring of a natural mussel bed in the same area was carried out weekly from June until August for TTXs and/or the presence of . Biotic (mussels, mesozooplankton, worms and phytoplankton); abiotic (water and sediment) matrices and phytoplankton assemblage characterizations were studied. Mussels showed relevant TTX contamination levels (9-296 µg kg) with extremely rapid TTX accumulation/depletion rates. The toxin presence in phytoplankton and its distribution in the different mussel tissues supports its possible exogenous origin. The count trend overlaps that of TTX contamination in mussels, and similar trends were reported also for some phytoplankton species. The role of carrying NRPS or PKS genes as a possible TTX source and of phytoplankton as a "potential vector" should therefore be further investigated.

摘要

河豚毒素 (TTXs) 是一种传统上与印度洋-太平洋地区相关的河豚鱼毒液，在过去几十年中，已在越来越广泛的海洋生物和地理区域中被报道，包括欧洲的贝类。研究表明，生长在马尔凯地区（意大利北部亚得里亚海）的野生贻贝在温暖季节容易受到 TTX 污染，其原因可能与一种非核糖体肽合成酶 (NRPS) 和聚酮合酶 (PKS) 编码基因特征有关。本研究旨在深入了解毒素的来源以及其在贻贝中积累的方式。一项为期两年的研究（2020 年春夏-2021 年）证实了 TTX（11-68 µg kg）在官方监测的科内罗里维埃拉天然贻贝床中反复出现。2021 年，在同一地区的一个天然贻贝床进行了补充的非例行监测，每周从 6 月到 8 月对 TTXs 和/或 进行监测。对生物（贻贝、中型浮游动物、蠕虫和浮游植物）；非生物（水和沉积物）矩阵和浮游植物组合特征进行了研究。贻贝表现出相关的 TTX 污染水平（9-296 µg kg），具有极快的 TTX 积累/消耗速率。浮游植物中存在毒素及其在不同贻贝组织中的分布支持其可能的外源性起源。的计数趋势与贻贝中 TTX 污染的趋势重叠，一些浮游植物物种也报告了类似的趋势。因此，应进一步研究携带 NRPS 或 PKS 基因的 作为可能的 TTX 来源以及浮游植物作为“潜在载体”的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/3004b598c6af/marinedrugs-21-00008-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/b57769da2c5b/marinedrugs-21-00008-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/7f181cdb82e6/marinedrugs-21-00008-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/f62375f2097b/marinedrugs-21-00008-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/17cd09031af8/marinedrugs-21-00008-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/085b3766091a/marinedrugs-21-00008-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/7f0aaff5028d/marinedrugs-21-00008-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/7612b69ad5f0/marinedrugs-21-00008-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/3004b598c6af/marinedrugs-21-00008-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/b57769da2c5b/marinedrugs-21-00008-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/7f181cdb82e6/marinedrugs-21-00008-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/f62375f2097b/marinedrugs-21-00008-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/17cd09031af8/marinedrugs-21-00008-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/085b3766091a/marinedrugs-21-00008-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/7f0aaff5028d/marinedrugs-21-00008-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/7612b69ad5f0/marinedrugs-21-00008-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8acf/9866420/3004b598c6af/marinedrugs-21-00008-g008.jpg

相似文献

1
A Hotspot of TTX Contamination in the Adriatic Sea: Study on the Origin and Causative Factors.亚得里亚海的 TTX 污染热点：起源与成因研究。
Mar Drugs. 2022 Dec 22;21(1):8. doi: 10.3390/md21010008.
2
Tetrodotoxins (TTXs) and in Mussels from Central Adriatic Sea (Italy): Are They Closely Related?贝类中麻痹性贝类毒素（TTXs）和石房蛤毒素（STXs）：它们是否密切相关？
Mar Drugs. 2021 May 25;19(6):304. doi: 10.3390/md19060304.
3
First detection of tetrodotoxin and high levels of paralytic shellfish poisoning toxins in shellfish from Sicily (Italy) by three different analytical methods.三种不同分析方法首次检测到来自西西里岛（意大利）贝类中的河豚毒素和高浓度麻痹性贝类毒素。
Chemosphere. 2019 Jan;215:881-892. doi: 10.1016/j.chemosphere.2018.10.081. Epub 2018 Oct 15.
4
Detection of Tetrodotoxin Shellfish Poisoning (TSP) Toxins and Causative Factors in Bivalve Molluscs from the UK.检测来自英国双壳贝类软体动物的河豚毒素贝类中毒（TSP）毒素和病因。
Mar Drugs. 2017 Aug 30;15(9):277. doi: 10.3390/md15090277.
5
Tetrodotoxin in bivalve mollusks: An integrated study towards the comprehension of the influencing factors of a newly native phenomenon.双壳贝类中的河豚毒素：对一个新的本地现象影响因素的综合研究。
Chemosphere. 2023 Oct;339:139682. doi: 10.1016/j.chemosphere.2023.139682. Epub 2023 Jul 30.
6
Two-year study of lipophilic marine toxin profile in mussels of the North-central Adriatic Sea: First report of azaspiracids in Mediterranean seafood.亚得里亚海中部北部贻贝中亲脂性海洋毒素特征的两年研究：地中海海产品中azaspiracids的首次报告。
Toxicon. 2015 Dec 15;108:115-25. doi: 10.1016/j.toxicon.2015.10.002. Epub 2015 Oct 9.
7
First Detection of Tetrodotoxin in Greek Shellfish by UPLC-MS/MS Potentially Linked to the Presence of the Dinoflagellate Prorocentrum minimum.通过超高效液相色谱-串联质谱法首次在希腊贝类中检测到河豚毒素，这可能与微小原甲藻的存在有关。
Toxins (Basel). 2015 May 20;7(5):1779-807. doi: 10.3390/toxins7051779.
8
Preliminary Results on the Evaluation of the Occurrence of Tetrodotoxin Associated to Marine Vibrio spp. in Bivalves from the Galician Rias (Northwest of Spain).海洋弧菌引起的贝类麻痹性贝类毒素相关初步评估结果。西班牙西北部加利西亚河口
Mar Drugs. 2018 Mar 6;16(3):81. doi: 10.3390/md16030081.
9
The occurrence of lipophilic toxins in shellfish from the Middle Adriatic Sea.贝类中脂溶性毒素的出现。
Toxicon. 2020 Oct 30;186:19-25. doi: 10.1016/j.toxicon.2020.07.026. Epub 2020 Jul 30.
10
Development and validation of a maleimide-based enzyme-linked immunosorbent assay for the detection of tetrodotoxin in oysters and mussels.基于马来酰亚胺的酶联免疫吸附法的建立及其在贝类中河豚毒素检测的应用。
Talanta. 2018 Jan 1;176:659-666. doi: 10.1016/j.talanta.2017.08.058. Epub 2017 Aug 18.

引用本文的文献

1
Searching for Paralytic Toxin, Tetrodotoxin, in Swedish Bivalve Shellfish.在瑞典双壳贝类中寻找麻痹性毒素——河豚毒素。
Mar Drugs. 2025 Jun 19;23(6):257. doi: 10.3390/md23060257.
2
An Update of Tetrodotoxins Toxicity and Risk Assessment Associated to Contaminated Seafood Consumption in Europe: A Systematic Review.欧洲因食用受污染海鲜导致的河豚毒素毒性及风险评估最新情况：一项系统综述
Toxins (Basel). 2025 Feb 8;17(2):76. doi: 10.3390/toxins17020076.
3
Investigating Non-Native Ribbon Worm as a Potential Source of Tetrodotoxin in British Bivalve Shellfish.

本文引用的文献

1
Tetrodotoxins in French Bivalve Mollusks-Analytical Methodology, Environmental Dynamics and Screening of Bacterial Strain Collections.法国双壳贝类中的河豚毒素——分析方法学、环境动态和细菌菌株集的筛选。
Toxins (Basel). 2021 Oct 20;13(11):740. doi: 10.3390/toxins13110740.
2
The role of toxic planocerid flatworm larvae on tetrodotoxin accumulation in marine bivalves.海洋双壳贝类体内河豚毒素积累与有毒平壳涡虫幼虫的关系
Aquat Toxicol. 2021 Aug;237:105908. doi: 10.1016/j.aquatox.2021.105908. Epub 2021 Jul 6.
3
Tetrodotoxins (TTXs) and in Mussels from Central Adriatic Sea (Italy): Are They Closely Related?
调查非本地带绦虫是否为英国双壳贝类中河豚毒素的潜在来源。
Mar Drugs. 2024 Oct 5;22(10):458. doi: 10.3390/md22100458.
4
First Toxicological Analysis of the Pufferfish Collected in Italian Waters (Strait of Sicily): Role of Citizens Science in Monitoring Toxic Marine Species.意大利海域（西西里海峡）采集的河豚的首次毒理学分析：公民科学在监测有毒海洋物种中的作用。
Animals (Basel). 2023 Jun 4;13(11):1873. doi: 10.3390/ani13111873.
5
New Vectors of TTX Analogues in the North Atlantic Coast: The Edible Crabs and .北太西洋贻贝类和食用蟹体内新的 TTX 类似物：
Mar Drugs. 2023 May 25;21(6):320. doi: 10.3390/md21060320.
贝类中麻痹性贝类毒素（TTXs）和石房蛤毒素（STXs）：它们是否密切相关？
Mar Drugs. 2021 May 25;19(6):304. doi: 10.3390/md19060304.
4
Seasonal and Spatial Variations in Bacterial Communities From Tetrodotoxin-Bearing and Non-tetrodotoxin-Bearing Clams.携带河豚毒素和不携带河豚毒素的蛤类中细菌群落的季节和空间变化
Front Microbiol. 2020 Aug 5;11:1860. doi: 10.3389/fmicb.2020.01860. eCollection 2020.
5
Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods.海洋双壳贝类和腹足类动物中存在河豚毒素（TTX）及TTX类似物对公众健康造成的风险。
EFSA J. 2017 Apr 20;15(4):e04752. doi: 10.2903/j.efsa.2017.4752. eCollection 2017 Apr.
6
Taxonomic Distribution of Tetrodotoxin in Acotylean Flatworms (Polycladida: Platyhelminthes).涡虫纲（扁形动物门：扁形动物）中的河豚毒素的分类分布。
Mar Biotechnol (NY). 2020 Dec;22(6):805-811. doi: 10.1007/s10126-020-09968-1. Epub 2020 May 15.
7
The planocerid flatworm is a main supplier of toxin to tetrodotoxin-bearing fish juveniles.平角涡虫是含河豚毒素幼鱼的主要毒素供应源。
Chemosphere. 2020 Jun;249:126217. doi: 10.1016/j.chemosphere.2020.126217. Epub 2020 Feb 14.
8
Toxic Flatworm Egg Plates Serve as a Possible Source of Tetrodotoxin for Pufferfish.毒裂头绦虫卵板可能是河豚鱼体内河豚毒素的来源。
Toxins (Basel). 2019 Jul 11;11(7):402. doi: 10.3390/toxins11070402.
9
First detection of tetrodotoxin and high levels of paralytic shellfish poisoning toxins in shellfish from Sicily (Italy) by three different analytical methods.三种不同分析方法首次检测到来自西西里岛（意大利）贝类中的河豚毒素和高浓度麻痹性贝类毒素。
Chemosphere. 2019 Jan;215:881-892. doi: 10.1016/j.chemosphere.2018.10.081. Epub 2018 Oct 15.
10
First Report on the Occurrence of Tetrodotoxins in Bivalve Mollusks in The Netherlands.荷兰双壳贝类中存在河豚毒素的首次报告。
Toxins (Basel). 2018 Nov 1;10(11):450. doi: 10.3390/toxins10110450.