真菌的苄醇/水杨醛型聚酮化合物代谢物：来源、生物合成、生物活性和合成。

Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis.

机构信息

Department of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinskeho 9, SK-812 37 Bratislava, Slovakia.

出版信息

Mar Drugs. 2022 Dec 27;21(1):19. doi: 10.3390/md21010019.

DOI:10.3390/md21010019

PMID:36662192

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9860963/

Abstract

Marine microorganisms are an important source of natural polyketides, which have become a significant reservoir of lead structures for drug design due to their diverse biological activities. In this review, we provide a summary of the resources, structures, biological activities, and proposed biosynthetic pathways of the benzyl alcohol/salicylaldehyde-type polyketides. In addition, the total syntheses of these secondary metabolites from their discoveries to the present day are presented. This review could be helpful for researchers in the total synthesis of complex natural products and the use of polyketide bioactive molecules for pharmacological purposes and applications in medicinal chemistry.

摘要

海洋微生物是天然聚酮化合物的重要来源，由于其具有多样的生物活性，已成为药物设计中先导结构的重要来源。在这篇综述中，我们总结了苯甲醇/水杨醛型聚酮类化合物的资源、结构、生物活性和推测的生物合成途径。此外，还介绍了从发现到现在这些次级代谢物的全合成。本文的综述对于复杂天然产物的全合成以及聚酮类生物活性分子在药理学和药物化学中的应用的研究人员可能会有所帮助。