海洋海绵来源真菌 XWS03F09 的细胞毒性聚酮化合物。
Cytotoxic Polyketides from the Marine Sponge-Derived Fungus XWS03F09.
机构信息
School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China.
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
出版信息
Molecules. 2019 Jul 22;24(14):2655. doi: 10.3390/molecules24142655.
Four new compounds, including two new polyketides, heterocornols M and N (, ), and a pair of epimers, heterocornols O and P (, ), were isolated from the fermentation broth of the marine sponge-derived fungus XWS03F09, together with three known compounds (-). The new chemical structures were established on the basis of a spectroscopic analysis, optical rotation, experimental and calculated electronic circular dichroism (ECD). All of the compounds (-) were evaluated for their cytotoxic activities, and heterocornols M-P (-) exhibited cytotoxicities against four human cancer cell lines with IC values of 20.4-94.2 μM.
从海洋海绵来源的真菌 XWS03F09 的发酵液中分离得到了四个新化合物，包括两个新的聚酮类化合物heterocornols M 和 N (1 和 2)，以及一对差向异构体 heterocornols O 和 P (3 和 4)，以及三个已知化合物 (-)。新的化学结构是基于光谱分析、旋光度、实验和计算的电子圆二色性 (ECD) 确定的。所有化合物 (-) 都进行了细胞毒性活性评估，化合物 heterocornols M-P (-) 对四种人癌细胞系具有细胞毒性，IC 值为 20.4-94.2 μM。
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