孕中期MCP-1水平作为早产预测指标的前瞻性研究。
A Prospective Study of Mid-Trimester MCP-1 Levels as a Predictor of Preterm Delivery.
作者信息
Bogavac Mirjana A, Ćelić Dejan D, Perić Tamara M
机构信息
Clinical Center of Vojvodina, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
Clinical Center of Vojvodina, Department of Nephrology and Clinical Immunology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
出版信息
Medicines (Basel). 2022 Dec 30;10(1):7. doi: 10.3390/medicines10010007.
Background: The prevention of preterm delivery (PTD) represents one of the major topics in modern obstetrics. The aim was to design a prospective study and investigate if mid-trimester serum and amniotic fluid levels of MCP-1 could predict the occurence of spontaneous PTD. Methods: The study involved 198 women who underwent genetic amniocentesis and blood sampling in the middle of their trimester. After applying the criteria for inclusion in the study, there were 16 respondents in the study group, and 38 respondents in the control group. Level of MCP-1 in amniotic fluid and serum was measured with commercially available enzyme-linked immunosorbent assays (ELISA) and statistical analysis was conducted. Results: There was no statistically significant difference in serum or amniotic fluid MCP1 levels between PTD and the control groups. Conclusion: The results suggest that MCP-1 is probably not the most relevant marker for predicting PTD. This study provides new normative data for MCP-1 levels in amniotic fluid and maternal sera and is a valuable tool for future diagnostic and comparative studies.
背景
预防早产是现代妇产科学的主要课题之一。本研究旨在设计一项前瞻性研究，探讨孕中期血清和羊水MCP - 1水平能否预测自发性早产的发生。方法：本研究纳入198名在孕中期接受遗传羊膜腔穿刺术和采血的女性。在应用纳入标准后，研究组有16名受试者，对照组有38名受试者。采用市售酶联免疫吸附测定（ELISA）法测定羊水和血清中MCP - 1水平，并进行统计分析。结果：早产组与对照组的血清或羊水MCP1水平无统计学显著差异。结论：结果表明，MCP - 1可能不是预测早产的最相关标志物。本研究提供了羊水和母血清中MCP - 1水平的新规范数据，是未来诊断和比较研究的宝贵工具。
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