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1888年(博尔顿)J. 施罗特的生物活性分析:对其在促进女性生殖健康方面可能应用的启示

Bioactivity Profiling of (Bolton) J. Schröt. 1888: Implications for Its Possible Application in Enhancing Women's Reproductive Health.

作者信息

Ilić Djordje, Karaman Maja, Bogavac Mirjana, Mišković Jovana, Rašeta Milena

机构信息

Clinical Centre of Vojvodina, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.

ProFungi Laboratory, Department of Biology and Ecology, Faculty of Sciences University of Novi Sad, Trg Dositeja Obradovića 2, 21000 Novi Sad, Serbia.

出版信息

Pharmaceuticals (Basel). 2024 May 8;17(5):600. doi: 10.3390/ph17050600.

Abstract

This study investigates the bioactivity profile of wood-rotting fungal species (Bolton) J. Schröt. 1888, focusing on its antioxidant, cytotoxic, and genotoxic activities and enzyme modulation properties with respect to its possible application in terms of enhancing women's reproductive health. Two types of extracts, including those based on EtOH extraction (DC) and hydrodistillation (DCHD), were investigated. The results indicate that the radical scavenging capacity against the DPPH radical and reduction potential were stronger in the DC extracts owing to the higher total phenolic content (TPC) and total flavonoid content (TFC) (25.30 ± 1.05 mg GAE/g d.w. and 2.84 ± 0.85 mg QE/g d.w., respectively). The same trend was observed in the protein phosphatase-1 (PP1) activity and in the genotoxic activity against the δ virus since only the DC extract exhibited DNA disintegration regarding a dilution of 1:100. Conversely, the DCHD extract exhibited increased hemolytic and cytotoxic effects (339.39% and IC = 27.76 ± 0.89 μg/mL-72 h incubation, respectively), along with greater inhibition of the AChE enzyme (IC = 3.11 ± 0.45 mg/mL) and hemolytic activity. These results suggest that terpenoids and steroids may be responsible for the observed activity in DCHD as these compounds could potentially be extracted following the HD procedure. This comprehensive bioactivity profiling offers valuable insights into the potential therapeutic applications of from Serbia and underscores the importance of further investigations for harnessing its pharmacological potential.

摘要

本研究调查了木腐真菌物种(博尔顿)J.施罗特1888年的生物活性谱,重点关注其抗氧化、细胞毒性和遗传毒性活性以及酶调节特性,以探讨其在促进女性生殖健康方面的潜在应用。研究了两种提取物,包括乙醇提取(DC)提取物和水蒸馏(DCHD)提取物。结果表明,由于总酚含量(TPC)和总黄酮含量(TFC)较高(分别为25.30±1.05毫克没食子酸当量/克干重和2.84±0.85毫克槲皮素当量/克干重),DC提取物对DPPH自由基的清除能力和还原电位更强。在蛋白磷酸酶-1(PP1)活性和针对δ病毒的遗传毒性活性方面也观察到了相同的趋势,因为只有DC提取物在1:100稀释时表现出DNA分解。相反,DCHD提取物表现出增加的溶血和细胞毒性作用(分别为339.39%和IC = 27.76±0.89微克/毫升 - 72小时孵育),以及对乙酰胆碱酯酶(AChE)的更大抑制作用(IC = 3.11±0.45毫克/毫升)和溶血活性。这些结果表明,萜类化合物和类固醇可能是DCHD中观察到的活性的原因,因为这些化合物可能可以通过水蒸馏程序提取出来。这种全面的生物活性分析为塞尔维亚的[具体真菌名称未给出]的潜在治疗应用提供了有价值的见解,并强调了进一步研究以利用其药理潜力的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d47/11123820/57bac2b2dc23/pharmaceuticals-17-00600-g001.jpg

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