患有泰里恩边缘性角膜变性患者泪液中的溶酶体酶

Lysosomal enzymes in tear fluids from patients with Terrien's marginal corneal degeneration.

作者信息

Hayasaka S, Tsuchiya M, Sekimoto M, Noda S, Shibuya Y, Setogawa T

机构信息

Department of Ophthalmology, Shimane Medical University, Japan.

出版信息

Graefes Arch Clin Exp Ophthalmol. 1987;225(5):335-7. doi: 10.1007/BF02153400.

DOI:10.1007/BF02153400

PMID:3666476

Abstract

We examined biochemically the lysosomal enzyme activities in tear fluids from patients with mild myopia, senile cataract, and Terrien's marginal corneal degeneration. Tear acid phosphatase activities in Terrien's degeneration were almost the same as those in mild myopia and senile cataract, while those of N-acetyl-beta-D-glucosaminidase in Terrien's degeneration were higher. The high activity of tear N-acetyl-beta-D-glucosaminidase may be derived from the lacrimal gland and infiltrate histiocytelike cells in Terrien's marginal corneal degeneration.

摘要

我们对轻度近视、老年性白内障和泰里恩边缘性角膜变性患者泪液中的溶酶体酶活性进行了生化检测。泰里恩变性患者泪液中的酸性磷酸酶活性与轻度近视和老年性白内障患者的几乎相同，而泰里恩变性患者的N-乙酰-β-D-氨基葡萄糖苷酶活性较高。泪液中N-乙酰-β-D-氨基葡萄糖苷酶的高活性可能来源于泪腺，并浸润泰里恩边缘性角膜变性中的组织细胞样细胞。