免疫在神经退行性疾病的肠-脑轴中架起了一座桥梁。
Immunity orchestrates a bridge in gut-brain axis of neurodegenerative diseases.
作者信息
Cheng Yufeng, Chen Ce, Zhang Feng
机构信息
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education and Key Laboratory of Basic Pharmacology of Guizhou Province and Laboratory Animal Centre, Zunyi Medical University, Zunyi, Guizhou, China.
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education and Key Laboratory of Basic Pharmacology of Guizhou Province and Laboratory Animal Centre, Zunyi Medical University, Zunyi, Guizhou, China; Sino-Jan Joint Lab of Natural Health Products Research, School of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing, China.
出版信息
Ageing Res Rev. 2023 Mar;85:101857. doi: 10.1016/j.arr.2023.101857. Epub 2023 Jan 17.
Neurodegenerative diseases, in particular for Alzheimer's disease (AD), Parkinson's disease (PD) and Multiple sclerosis (MS), are a category of diseases with progressive loss of neuronal structure or function (encompassing neuronal death) leading to neuronal dysfunction, whereas the underlying pathogenesis remains to be clarified. As the microbiological ecosystem of the intestinal microbiome serves as the second genome of the human body, it is strongly implicated as an essential element in the initiation and/or progression of neurodegenerative diseases. Nevertheless, the precise underlying principles of how the intestinal microflora impact on neurodegenerative diseases via gut-brain axis by modulating the immune function are still poorly characterized. Consequently, an overview of initiating the development of neurodegenerative diseases and the contribution of intestinal microflora on immune function is discussed in this review.
神经退行性疾病，特别是阿尔茨海默病（AD）、帕金森病（PD）和多发性硬化症（MS），是一类神经元结构或功能逐渐丧失（包括神经元死亡）导致神经元功能障碍的疾病，但其潜在发病机制仍有待阐明。由于肠道微生物群的微生物生态系统作为人体的第二基因组，它被强烈认为是神经退行性疾病发生和/或进展的一个重要因素。然而，肠道微生物群如何通过调节免疫功能经肠-脑轴影响神经退行性疾病的确切潜在机制仍知之甚少。因此，本综述讨论了神经退行性疾病发生发展的概况以及肠道微生物群对免疫功能的作用。
Zotero 插件