Biochemistry and Molecular Biology Laboratory, Department of Zoology, Faculty of Science, University of Delhi, Delhi, India.
Department of Biotechnology, Delhi Technical University, Delhi, India.
Life Sci. 2023 Oct 1;330:122022. doi: 10.1016/j.lfs.2023.122022. Epub 2023 Aug 12.
Emerging evidence have shown the importance of gut microbiota in regulating brain functions. The diverse molecular mechanisms involved in cross-talk between gut and brain provide insight into importance of this communication in maintenance of brain homeostasis. It has also been observed that disturbed gut microbiota contributes to neurological diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis and aging. Recently, gut microbiome-derived exosomes have also been reported to play an essential role in the development and progression of neurodegenerative diseases and could thereby act as a therapeutic target. Further, pharmacological interventions including antibiotics, prebiotics and probiotics can influence gut microbiome-mediated management of neurological diseases. However, extensive research is warranted to better comprehend this interconnection in maintenance of brain homeostasis and its implication in neurological diseases. Thus, the present review is aimed to provide a detailed understanding of gut-brain axis followed by possibilities to target the gut microbiome for improving neurological health.
越来越多的证据表明肠道微生物群在调节大脑功能方面的重要性。肠道和大脑之间相互作用所涉及的多样化分子机制为这种通讯在维持大脑内环境稳定中的重要性提供了深入了解。此外，肠道微生物群失调也被观察到与神经退行性疾病如阿尔茨海默病、帕金森病、多发性硬化症、肌萎缩侧索硬化症和衰老有关。最近，肠道微生物组衍生的外泌体也被报道在神经退行性疾病的发展和进展中发挥着重要作用，因此可以作为治疗靶点。此外，包括抗生素、益生元和益生菌在内的药物干预措施可以影响肠道微生物组介导的神经疾病的管理。然而，需要进行广泛的研究来更好地理解这种在维持大脑内环境稳定中的相互联系及其在神经疾病中的意义。因此，本综述旨在提供对肠道-大脑轴的详细了解，然后探讨针对肠道微生物组以改善神经健康的可能性。
