癸酸与黏菌素对黏菌素敏感及耐药菌株的协同作用
Synergistic Effects of Capric Acid and Colistin against Colistin-Susceptible and Colistin-Resistant .
作者信息
Liu Yi-Yun, Qin Zong-Hua, Yue Hui-Ying, Bergen Phillip J, Deng Li-Min, He Wan-Yun, Zeng Zhen-Ling, Peng Xian-Feng, Liu Jian-Hua
机构信息
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou 510642, China.
Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
出版信息
Antibiotics (Basel). 2022 Dec 26;12(1):36. doi: 10.3390/antibiotics12010036.
Colistin is a last-line antibiotic against Gram-negative pathogens. However, the emergence of colistin resistance has substantially reduced the clinical effectiveness of colistin. In this study, synergy between colistin and capric acid was examined against twenty-one Gram-negative bacterial isolates (four colistin-susceptible and seventeen colistin-resistant). Checkerboard assays showed a synergistic effect against all colistin-resistant strains [(FICI, fractional inhibitory concentration index) = 0.02-0.38] and two colistin-susceptible strains. Time-kill assays confirmed the combination was synergistic. We suggest that the combination of colistin and capric acid is a promising therapeutic strategy against Gram-negative colistin-resistant strains.
黏菌素是对抗革兰氏阴性病原体的最后一线抗生素。然而，黏菌素耐药性的出现已大幅降低了黏菌素的临床疗效。在本研究中，检测了黏菌素与癸酸对21株革兰氏阴性细菌分离株（4株对黏菌素敏感，17株对黏菌素耐药）的协同作用。棋盘法检测显示对所有耐黏菌素菌株均有协同作用[（FICI，分数抑制浓度指数）=0.02 - 0.38]以及两株对黏菌素敏感的菌株。时间杀菌试验证实该组合具有协同作用。我们认为黏菌素与癸酸联合使用是对抗革兰氏阴性耐黏菌素菌株的一种有前景的治疗策略。
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