替加环素或黏菌素与齐多夫定联合对携带（X）和……的大肠杆菌的活性 。 需注意，原文中“(X) and.”表述不完整，可能会影响准确理解和完整翻译。
Activity of Tigecycline or Colistin in Combination with Zidovudine against Escherichia coli Harboring (X) and .
作者信息
Zhou Yu-Feng, Liu Ping, Dai Shu-He, Sun Jian, Liu Ya-Hong, Liao Xiao-Ping
机构信息
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.
出版信息
Antimicrob Agents Chemother. 2020 Dec 16;65(1). doi: 10.1128/AAC.01172-20.
Abstract
Alternative therapeutic options are urgently needed against multidrug-resistant infections, especially in situations of preexisting tigecycline and colistin resistance. Here, we investigated synergistic activity of the antiretroviral drug zidovudine in combination with tigecycline or colistin against harboring (X) and and in a murine thigh infection model. Zidovudine and tigecycline/colistin combinations achieved synergistic killing and significantly decreased bacterial burdens by >2.5-log CFU/g in thigh tissues compared to each monotherapy.
摘要
迫切需要针对多重耐药感染的替代治疗方案，尤其是在已存在替加环素和黏菌素耐药的情况下。在此，我们研究了抗逆转录病毒药物齐多夫定与替加环素或黏菌素联合使用对携带（X）以及在小鼠大腿感染模型中的协同活性。与单一疗法相比，齐多夫定与替加环素/黏菌素联合使用实现了协同杀伤，并使大腿组织中的细菌载量显著降低超过2.5个对数CFU/克。
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