Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Cells. 2023 Jan 7;12(2):255. doi: 10.3390/cells12020255.
The DNA repair machinery exists to protect cells from daily genetic insults by orchestrating multiple intrinsic and extrinsic factors. One such factor recently identified is the Runt-related transcription factor (RUNX) family, a group of proteins that act as a master transcriptional regulator for multiple biological functions such as embryonic development, stem cell behaviors, and oncogenesis. A significant number of studies in the past decades have delineated the involvement of RUNX proteins in DNA repair. Alterations in RUNX genes cause organ failure and predisposition to cancers, as seen in patients carrying mutations in the other well-established DNA repair genes. Herein, we review the currently existing findings and provide new insights into transcriptional and non-transcriptional multifaceted regulation of DNA repair by RUNX family proteins.
DNA 修复机制的存在是为了通过协调多种内在和外在因素来保护细胞免受日常遗传损伤。最近发现的一个这样的因素是 runt 相关转录因子 (RUNX) 家族，这组蛋白作为多个生物学功能的主要转录调节剂，如胚胎发育、干细胞行为和肿瘤发生。过去几十年的大量研究已经阐明了 RUNX 蛋白在 DNA 修复中的作用。RUNX 基因的改变会导致器官衰竭和癌症易感性，就像在携带其他成熟的 DNA 修复基因突变的患者中一样。在此，我们回顾了目前已有的发现，并提供了关于 RUNX 家族蛋白对 DNA 修复的转录和非转录多方面调控的新见解。
