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法医遗传学和基因组学:远不止是人类的事情。

Forensic genetics and genomics: Much more than just a human affair.

作者信息

Arenas Miguel, Pereira Filipe, Oliveira Manuela, Pinto Nadia, Lopes Alexandra M, Gomes Veronica, Carracedo Angel, Amorim Antonio

机构信息

Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain.

Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal.

出版信息

PLoS Genet. 2017 Sep 21;13(9):e1006960. doi: 10.1371/journal.pgen.1006960. eCollection 2017 Sep.

Abstract

While traditional forensic genetics has been oriented towards using human DNA in criminal investigation and civil court cases, it currently presents a much wider application range, including not only legal situations sensu stricto but also and, increasingly often, to preemptively avoid judicial processes. Despite some difficulties, current forensic genetics is progressively incorporating the analysis of nonhuman genetic material to a greater extent. The analysis of this material-including other animal species, plants, or microorganisms-is now broadly used, providing ancillary evidence in criminalistics in cases such as animal attacks, trafficking of species, bioterrorism and biocrimes, and identification of fraudulent food composition, among many others. Here, we explore how nonhuman forensic genetics is being revolutionized by the increasing variety of genetic markers, the establishment of faster, less error-burdened and cheaper sequencing technologies, and the emergence and improvement of models, methods, and bioinformatics facilities.

摘要

虽然传统法医遗传学一直专注于在刑事调查和民事法庭案件中使用人类DNA,但目前它的应用范围要广泛得多,不仅包括狭义的法律情况,而且越来越多地用于预先避免司法程序。尽管存在一些困难,但当前的法医遗传学正在逐步更大程度地纳入对非人类遗传物质的分析。对这种物质的分析——包括其他动物物种、植物或微生物——现在被广泛使用,在动物袭击、物种贩运、生物恐怖主义和生物犯罪以及识别欺诈性食品成分等许多案件的刑事调查中提供辅助证据。在这里,我们探讨了随着遗传标记种类的增加、更快、错误负担更小且更便宜的测序技术的建立以及模型、方法和生物信息学设施的出现和改进,非人类法医遗传学是如何发生变革的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cb7/5608170/2b646e60b594/pgen.1006960.g001.jpg

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