子宫内膜异位症患者的长非编码 RNA 表达：一项初步研究。
Long Non-Coding RNA Expression in Women with Endometriosis: A Pilot Study.
机构信息
Department of Gynaecology, Oncological Gynaecology and Endometriosis Treatment, Polish Mother's Memorial Hospital Research Institute, 93-338 Lodz, Poland.
Laboratory of Cancer Genetics, Department of Pathology, Polish Mother's Memorial Hospital Research Institute, Rzgowska 281/289, 93-338 Lodz, Poland.
出版信息
Genes (Basel). 2023 Jan 5;14(1):152. doi: 10.3390/genes14010152.
BACKGROUND
Endometriosis is a chronic disease of the genital organs that mainly affects women of reproductive age. The analysis of long non-coding RNA (lncRNA) in endometriosis is a novel field of science. Recently, attention has been drawn to , which is incorrectly expressed in various human diseases, including endometriosis.
AIM
The aim of this pilot study was to analyze the expression of lncRNA small nucleolar RNA host gene 4 () and to investigate its significance in endometriosis.
MATERIAL AND METHODS
LncRNA expression was investigated in paraffin blocks in endometriosis patients (n = 100) and in endometriosis-free controls (n = 100) using a real-time PCR assay.
RESULTS
This study revealed a higher expression of in endometriosis patients than in controls. A statistically significant relationship between expression level and was found in relation to The Revised American Society for Reproductive Medicine classification of endometriosis, 1996, in the group of patients with endometriosis.
CONCLUSION
This pilot study has revealed that gene expression in plays an important role in the pathogenesis of endometriosis.
背景
子宫内膜异位症是一种生殖器官的慢性疾病，主要影响育龄妇女。对长链非编码 RNA（lncRNA）在子宫内膜异位症中的分析是一个新兴的科学领域。最近，人们关注到，它在包括子宫内膜异位症在内的各种人类疾病中表达异常。
目的
本初步研究旨在分析 lncRNA 小核仁 RNA 宿主基因 4（）的表达，并探讨其在子宫内膜异位症中的意义。
材料和方法
使用实时 PCR 检测 100 例子宫内膜异位症患者和 100 例无子宫内膜异位症对照的石蜡块中 lncRNA 的表达。
结果
本研究显示，子宫内膜异位症患者的表达高于对照组。在子宫内膜异位症患者组中，与 1996 年修订的美国生殖医学协会子宫内膜异位症分类相关，发现表达水平与之间存在统计学显著关系。
结论
本初步研究表明，基因在子宫内膜异位症发病机制中发挥重要作用。
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