Huynh Trang Nguyen-Mai, Yamazaki Fumikazu, Kishimoto Izumi, Tanaka Akihiro, Son Yonsu, Ozaki Yoshio, Takehana Kazuya, Tanizaki Hideaki
Department of Dermatology, Kansai Medical University, Osaka 573-1010, Japan.
Psoriasis Center, Kansai Medical University, Osaka 573-1191, Japan.
Diagnostics (Basel). 2023 Jan 11;13(2):274. doi: 10.3390/diagnostics13020274.
Psoriasis is known as an independent risk factor for cardiovascular disease due to its chronic inflammation. Studies have been conducted to evaluate the progress of atherosclerotic plaques in psoriasis. However, inadequate efforts have been made to clarify the relationship between atherosclerosis progress in coronary arteries and other important blood vessels. For that reason, we investigated the correlation and development of the coronary artery calcification score (CACS) and the abdominal aortic calcification score (AACS) during a follow-up examination. Eighty-three patients with psoriasis underwent coronary computed tomography angiography (CCTA) for total CACS and abdominal computed tomography (AbCT) for total AACS. PASI score, other clinical features, and blood samples were collected at the same time. The patients' medical histories were also retrieved for further analysis. Linear regression was used to analyze the CACS and AACS associations. There was a moderate correlation between CACS and AACS, while both calcification scores relatively reflected the coronary plaque number, coronary stenosis number, and stenosis severity observed with CCTA. Both calcification scores were independent of the PASI score. However, a significantly higher CACS was found in psoriatic arthritis, whereas no similar phenomenon was recorded for AACS. To conclude, both CACS and AACS might be potential alternative tests to predict the presence of coronary lesions as confirmed by CCTA.
银屑病因其慢性炎症而被认为是心血管疾病的独立危险因素。已有研究对银屑病患者动脉粥样硬化斑块的进展情况进行评估。然而，对于冠状动脉及其他重要血管中动脉粥样硬化进展之间的关系，尚未进行充分研究。因此，我们在一项随访检查中，对冠状动脉钙化评分（CACS）和腹主动脉钙化评分（AACS）的相关性及发展情况进行了调查。83例银屑病患者接受了冠状动脉计算机断层血管造影（CCTA）以获取总CACS，并接受腹部计算机断层扫描（AbCT）以获取总AACS。同时收集银屑病面积和严重程度指数（PASI）评分、其他临床特征及血样。还调取了患者的病史以进行进一步分析。采用线性回归分析CACS和AACS的相关性。CACS与AACS之间存在中度相关性，且两项钙化评分均相对反映了CCTA观察到的冠状动脉斑块数量、冠状动脉狭窄数量及狭窄严重程度。两项钙化评分均与PASI评分无关。然而，在银屑病关节炎患者中发现CACS显著更高，而AACS未出现类似现象。总之，CACS和AACS可能都是预测经CCTA证实的冠状动脉病变存在的潜在替代检查方法。
