Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.
Department of Molecular Pathophysiology, School of Medicine, Shinshu University, Nagano, Japan; Institute for Biomedical Sciences, Shinshu University, Nagano, Japan.
Atherosclerosis. 2020 Nov;313:20-25. doi: 10.1016/j.atherosclerosis.2020.09.013. Epub 2020 Sep 23.
Dysfunctional high-density lipoprotein (HDL) is a risk factor for cardiovascular disease (CVD) beyond HDL concentrations. Recently, a novel method has been introduced to measure LOX-1 ligand containing apolipoprotein AI (LAA), which is an indicator of various types of modified HDL with binding capacity to LOX-1 and related to impaired anti-atherogenic functions of HDL. This study aimed to examine the relationship between LAA as a novel marker of dysfunctional HDL and coronary artery calcification (CAC).
We selected 910 community-dwelling Japanese men aged 40-79 years without a history of CVD. The odds ratios per 1SD of LAA for the presence of CAC (Agatston score >10) were estimated using logistic regression model adjusted for confounders, including HDL-C or HDL particle (HDL-P) concentration. In addition, we performed further analysis stratified by age (<65 and ≥ 65 years).
The mean age of the participants was 63.6 years, and the median LAA was 187.0 ng/mL. The prevalent CAC was 46.2%. The multivariable adjusted odds ratio (95% confidence interval) per 1SD of LAA for CAC was 1.14 (0.96-1.36) for all participants. After stratification by age, multivariable adjusted odds ratios per 1SD of LAA were 1.34 (1.02-1.76) and 0.97 (0.77-1.23) in men aged <65 and ≥ 65 years, respectively.
The present study showed that LAA was associated with CAC independent of HDL-C or HDL-P in middle-aged Japanese men. This finding suggests that LAA might be an early marker for CVD events. Future longitudinal studies are warranted.
异常的高密度脂蛋白（HDL）是心血管疾病（CVD）的一个风险因素，超出了 HDL 浓度的范围。最近，一种新的方法被引入来测量载脂蛋白 AI（apoAI）中的 LOX-1 配体（LAA），它是具有 LOX-1 结合能力的各种类型修饰型 HDL 的标志物，与 HDL 的抗动脉粥样硬化功能受损有关。本研究旨在探讨作为异常 HDL 新型标志物的 LAA 与冠状动脉钙化（CAC）之间的关系。
我们选择了 910 名年龄在 40-79 岁、无 CVD 病史的社区居住的日本男性。使用逻辑回归模型，在校正了包括 HDL-C 或 HDL 颗粒（HDL-P）浓度在内的混杂因素后，估计 LAA 每增加 1SD 时 CAC（Agatston 评分>10）的比值比。此外，我们还根据年龄（<65 岁和≥65 岁）进行了进一步的分层分析。
参与者的平均年龄为 63.6 岁，中位数 LAA 为 187.0ng/mL。CAC 的患病率为 46.2%。LAA 每增加 1SD 时 CAC 的多变量调整比值比（95%置信区间）为 1.14（0.96-1.36），所有参与者均如此。按年龄分层后，LAA 每增加 1SD 时的多变量调整比值比分别为<65 岁男性 1.34（1.02-1.76）和≥65 岁男性 0.97（0.77-1.23）。
本研究表明，在中年日本男性中，LAA 与 CAC 独立于 HDL-C 或 HDL-P 相关。这一发现表明，LAA 可能是 CVD 事件的早期标志物。需要进一步的前瞻性研究。
