Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Department of Pathology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Int J Mol Sci. 2023 Jan 5;24(2):1057. doi: 10.3390/ijms24021057.
Pancreatitis (acute and chronic) is an inflammatory disease associated with significant morbidity, including a high rate of hospitalization and mortality. MicroRNAs (miRs) are essential post-transcriptional modulators of gene expression. They are crucial in many diseases' development and progression. Recent studies have demonstrated aberrant miRs expression patterns in pancreatic tissues obtained from patients experiencing acute and chronic pancreatitis compared to tissues from unaffected individuals. Increasing evidence showed that miRs regulate multiple aspects of pancreatic acinar biology, such as autophagy, mitophagy, and migration, impact local and systemic inflammation and, thus, are involved in the disease development and progression. Notably, multiple miRs act on pancreatic acinar cells and regulate the transduction of signals between pancreatic acinar cells, pancreatic stellate cells, and immune cells, and provide a complex interaction network between these cells. Importantly, recent studies from various animal models and patients' data combined with advanced detection techniques support their importance in diagnosing and treating pancreatitis. In this review, we plan to provide an up-to-date summary of the role of miRs in the development and progression of pancreatitis.
胰腺炎（急性和慢性）是一种炎症性疾病，与较高的发病率相关，包括高住院率和死亡率。微小 RNA（miRs）是基因表达的重要转录后调节因子。它们在许多疾病的发展和进展中起着关键作用。最近的研究表明，与正常组织相比，在患有急性和慢性胰腺炎的患者的胰腺组织中存在异常的 miR 表达模式。越来越多的证据表明，miRs 调节胰腺腺泡生物学的多个方面，如自噬、线粒体自噬和迁移，影响局部和全身炎症，因此参与疾病的发展和进展。值得注意的是，多种 miR 作用于胰腺腺泡细胞，并调节胰腺腺泡细胞、胰腺星状细胞和免疫细胞之间的信号转导，为这些细胞之间提供了一个复杂的相互作用网络。重要的是，来自各种动物模型和患者数据的最近研究以及先进的检测技术支持了它们在胰腺炎的诊断和治疗中的重要性。在这篇综述中，我们计划提供 miR 在胰腺炎发展和进展中的作用的最新总结。
