Pancreatic Research Group, South Western Sydney Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney 2052, Australia.
Pancreatic Research Group, South Western Sydney Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney 2052, Australia; Ingham Institute of Applied Medical Research, Sydney 2170, Australia.
Biochim Biophys Acta Rev Cancer. 2022 May;1877(3):188728. doi: 10.1016/j.bbcan.2022.188728. Epub 2022 Apr 3.
Pancreatic cancer (PC) is a devastating disease, offering poor mortality rates for patients. The current challenge being faced is the inability to diagnose patients in a timely manner, where potentially curative resection provides the best chance of survival. Recently, small/nanosized extracellular vesicles (sEVs), including exosomes, have gained significant preclinical and clinical attention due to their emerging roles in cancer progression and diagnosis. Extracellular vesicles (EVs) possess endogenous properties that offer stability and facilitate crossing of biological barriers for delivery of molecular cargo to cells, acting as a form of intercellular communication to regulate function and phenotype of recipient cells. This review provides an overview of the role of EVs, their subtypes and their oncogenic cargo (as characterised by targeted studies as well as agnostic '-omics' analyses) in the pathobiology of pancreatic cancer. The discussion covers the progress of 'omics technology' that has enabled elucidation of the molecular mechanisms that mediate the role of EVs and their cargo in pancreatic cancer progression.
胰腺癌（PC）是一种毁灭性疾病，患者死亡率很高。目前面临的挑战是无法及时诊断患者，而潜在的可治愈性切除为患者提供了最佳的生存机会。最近，由于其在癌症进展和诊断中的作用不断增加，小/纳米细胞外囊泡（sEVs），包括外泌体，引起了广泛关注。细胞外囊泡（EVs）具有内在特性，可提供稳定性并促进分子货物传递到细胞的生物屏障穿越，作为一种细胞间通讯形式，调节受体细胞的功能和表型。本文综述了 EVs 及其亚型及其致癌货物（通过靶向研究以及非靶向 '-omics' 分析进行特征描述）在胰腺癌发病机制中的作用。讨论涵盖了“组学技术”的进展，该技术使阐明介导 EVs 及其货物在胰腺癌进展中作用的分子机制成为可能。
