Proctor R A, Wick P, Hamill R J, Horstmeier P, Gullings-Handley J, Weisensel M, Brandt G
Department of Medical Microbiology, University of Wisconsin Medical School, Madison 53706.
J Antimicrob Chemother. 1987 Aug;20(2):223-31. doi: 10.1093/jac/20.2.223.
Coagulase-negative staphylococci are being implicated as pathogens with increasing frequency and this may in part be due to their development of resistance to a wide variety of antibiotics. Because vancomycin is the only drug generally available for treating these multiply resistant organisms, we have tested several combinations of antibiotics for activity in vitro against these organisms. These in-vitro studies suggested that rifampicin combined with either gentamicin or cefamandole might occasionally provide an efficacious alternative to vancomycin, while the novobiocin plus rifampicin combination might be an effective oral regimen against methicillin-resistant coagulase negative staphylococci. Resistance to co-trimoxazole was found in nearly all isolates tested.
凝固酶阴性葡萄球菌作为病原体的情况越来越常见，这可能部分归因于它们对多种抗生素产生了耐药性。由于万古霉素是目前唯一可用于治疗这些多重耐药菌的药物，我们测试了几种抗生素组合对这些细菌的体外活性。这些体外研究表明，利福平与庆大霉素或头孢孟多联合使用偶尔可能是万古霉素的有效替代方案，而新生霉素加利福平组合可能是治疗耐甲氧西林凝固酶阴性葡萄球菌的有效口服方案。几乎所有测试的分离株都对复方新诺明耐药。
