Udo E E, Jacob L E, Chugh T D
Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Microb Drug Resist. 1995 Winter;1(4):315-20. doi: 10.1089/mdr.1995.1.315.
This study investigated the incidence of antimicrobial resistance in clinically significant coagulase-negative staphylococci at the Mubarak Al Kabeer Hospital, Kuwait. A total of 104 isolates of coagulase-negative staphylococci consisting of S. epidermidis (67), S. haemolyticus (16), S. saprophyticus (6), S. simulans (2), S. hominis (4), S. albus (2), S. sciuri (3), S. warneri (2), S. capitis (1), and S. xylosus (1) were isolated from clinical specimens over a 6-7 month period and tested for resistance to 22 antibacterial agents and the ability to produce slime. They were all susceptible to vancomycin and mupirocin but intermediate resistance to teicoplanin was detected in seven isolates: 83 and 47.7% were resistant to penicillin G and methicillin, respectively, 57% were resistant to gentamicin, 49.5% to erythromycin, 50.4% to tetracycline, and 52.3% to trimethoprim. Resistance to heavy metals and the nucleic-acid binding compound was also detected. More than half of S. epidermidis, S. saprophyticus, S. simulans, S. hominis, and all of S. haemolyticus were multiply resistant to three or more groups of antibiotics and there was a significant association between slime production and resistance to multiple antimicrobial agents in S. epidermidis. The results revealed a high level of resistance to commonly used agents.
本研究调查了科威特穆巴拉克·卡比尔医院临床显著的凝固酶阴性葡萄球菌的抗菌药物耐药性发生率。在6至7个月的时间里，从临床标本中分离出总共104株凝固酶阴性葡萄球菌，包括表皮葡萄球菌（67株）、溶血葡萄球菌（16株）、腐生葡萄球菌（6株）、模仿葡萄球菌（2株）、人葡萄球菌（4株）、白色葡萄球菌（2株）、松鼠葡萄球菌（3株）、华纳葡萄球菌（2株）、头葡萄球菌（1株）和木糖葡萄球菌（1株），并检测它们对22种抗菌药物的耐药性以及产生黏液的能力。它们对万古霉素和莫匹罗星均敏感，但在7株分离株中检测到对替考拉宁的中度耐药：分别有83%和47.7%对青霉素G和甲氧西林耐药，57%对庆大霉素耐药，49.5%对红霉素耐药，50.4%对四环素耐药，52.3%对甲氧苄啶耐药。还检测到对重金属和核酸结合化合物的耐药性。超过一半的表皮葡萄球菌、腐生葡萄球菌、模仿葡萄球菌、人葡萄球菌以及所有溶血葡萄球菌对三组或更多组抗生素多重耐药，并在表皮葡萄球菌中黏液产生与对多种抗菌药物的耐药性之间存在显著关联。结果显示对常用药物的耐药水平较高。
