Department of Solid State Engineering, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského nám. 2, 162 06 Prague, Czech Republic.
Int J Mol Sci. 2023 Jan 11;24(2):1432. doi: 10.3390/ijms24021432.
Metal nanostructure-treated polymers are widely recognized as the key material responsible for a specific antibacterial response in medical-based applications. However, the finding of an optimal bactericidal effect in combination with an acceptable level of cytotoxicity, which is typical for metal nanostructures, prevents their expansion from being more significant so far. This study explores the possibility of firmly anchoring silver nanoparticles (AgNPs) into polyetherether ketone (PEEK) with a tailored surface morphology that exhibits laser-induced periodic surface structures (LIPSS). We demonstrated that laser-induced forward transfer technology is a suitable tool, which, under specific conditions, enables uniform decoration of the PEEK surface with AgNPs, regardless of whether the surface is planar or LIPSS structured. The antibacterial test proved that AgNPs-decorated LIPSS represents a more effective bactericidal protection than their planar counterparts, even if they contain a lower concentration of immobilized particles. Nanostructured PEEK with embedded AgNPs may open up new possibilities in the production of templates for replication processes in the construction of functional bactericidal biopolymers or may be directly used in tissue engineering applications.
金属纳米结构处理的聚合物被广泛认为是医疗应用中产生特定抗菌反应的关键材料。然而，迄今为止，金属纳米结构通常具有最佳杀菌效果和可接受的细胞毒性水平，这一发现阻止了它们的进一步广泛应用。本研究探索了将银纳米粒子（AgNPs）牢固地固定在聚醚醚酮（PEEK）中的可能性，其表面形貌经过精心设计，具有激光诱导周期性表面结构（LIPSS）。我们证明了激光诱导正向传输技术是一种合适的工具，在特定条件下，无论表面是平面还是具有 LIPSS 结构，它都可以使 PEEK 表面均匀地装饰 AgNPs。抗菌测试证明，AgNPs 修饰的 LIPSS 比其平面结构具有更有效的杀菌保护作用，即使它们含有较低浓度的固定颗粒。嵌入 AgNPs 的纳米结构 PEEK 可能为复制过程模板的生产开辟新的可能性，用于构建功能性杀菌生物聚合物，或者可以直接用于组织工程应用。
