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多发性硬化进展形式中的脱髓鞘与神经退行性变。

Myelinodegeneration vs. Neurodegeneration in MS Progressive Forms.

机构信息

Bank of Tissues and Cells, Hospices Civils de Lyon, Hôpital Edouard Herriot, Place d'Arsonval, F-69003 Lyon, France.

Stem-Cell and Brain Research Institute, 18 Avenue de Doyen Lépine, F-69500 Bron, France.

出版信息

Int J Mol Sci. 2023 Jan 13;24(2):1596. doi: 10.3390/ijms24021596.

DOI:10.3390/ijms24021596
PMID:36675111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9864662/
Abstract

In MS patients with a progressive form of the disease, the slow deterioration of neurological functions is thought to result from a combination of neuronal cell death, axonal damages and synaptic dysfunctions [...].

摘要

在患有进行性形式的多发性硬化症的患者中，神经功能的缓慢恶化被认为是神经元细胞死亡、轴突损伤和突触功能障碍的综合作用的结果[...]。

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Int J Mol Sci. 2022 Nov 30;23(23):14993. doi: 10.3390/ijms232314993.
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Myelin heterogeneity for assessing normal appearing white matter myelin damage in multiple sclerosis.用于评估多发性硬化症中正常外观白质髓鞘损伤的髓鞘异质性
J Neuroimaging. 2023 Mar;33(2):227-234. doi: 10.1111/jon.13069. Epub 2022 Nov 28.
3
Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration.脑膜中淋巴毒素-α的表达导致淋巴组织形成和神经退行性变。
Brain. 2022 Dec 19;145(12):4287-4307. doi: 10.1093/brain/awac232.
4
"Ependymal-in" Gradient of Thalamic Damage in Progressive Multiple Sclerosis.进行性多发性硬化症中丘脑损伤的室管膜内梯度。
Ann Neurol. 2022 Oct;92(4):670-685. doi: 10.1002/ana.26448. Epub 2022 Jul 30.
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