Tasaki M, Hanada K, Hashimoto I
Department of Dermatology, Hirosaki University School of Medicine, Japan.
J Dermatol. 1993 Jan;20(1):21-4. doi: 10.1111/j.1346-8138.1993.tb03823.x.
With the objective of comprehending abnormal metabolisms of the essential metals of zinc (Zn) and copper (Cu) in three groups of skin diseases, skin cancer, inflammatory diseases, and non-inflammatory disease, we measured serum levels of Zn and Cu in 151 cases of various cutaneous manifestations and estimated the significance of the ratios between the two metals (Cu/Zn). The serum level of Zn was significantly decreased in cases of bullous pemphigoid, decubitus ulcer, and alopecia areata. The serum level of Cu was elevated in cases of psoriasis, decubitus ulcer, and skin cancer. We observed no elevation of serum Zn level or abnormally depressed serum Cu level. The Cu/Zn ratio showed significantly different values among these three groups of the diseases, suggesting the utility of measuring Cu/Zn ratios for differential diagnosis over that of determining the serum level of Zn or Cu alone. It was also demonstrated that, in each skin disease, the Cu/Zn ratio clearly reflects the severity of the progress.
为了解锌（Zn）和铜（Cu）这两种必需金属在三组皮肤病（皮肤癌、炎症性疾病和非炎症性疾病）中的异常代谢情况，我们检测了151例各种皮肤表现患者的血清锌和铜水平，并评估了两种金属比值（铜/锌）的意义。大疱性类天疱疮、褥疮溃疡和斑秃患者的血清锌水平显著降低。银屑病、褥疮溃疡和皮肤癌患者的血清铜水平升高。我们未观察到血清锌水平升高或血清铜水平异常降低的情况。这三组疾病的铜/锌比值显示出显著差异，表明测量铜/锌比值在鉴别诊断中的作用优于单独测定血清锌或铜水平。此外还证明，在每种皮肤病中，铜/锌比值清楚地反映了病情进展的严重程度。
