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用于有机和无机材料沉积的绘图切割模板掩膜以及一种用于抗菌评估的新型快速、经济高效的技术。

Plotter Cut Stencil Masks for the Deposition of Organic and Inorganic Materials and a New Rapid, Cost Effective Technique for Antimicrobial Evaluations.

作者信息

Childs Andre, Pereira Jorge, Didier Charles M, Baksh Aliyah, Johnson Isaac, Castro Jorge Manrique, Davidson Edwin, Santra Swadeshmukul, Rajaraman Swaminathan

机构信息

Department of Material Science and Engineering, University of Central Florida, Orlando, FL 32816, USA.

Department of Chemistry, University of Central Florida, Orlando, FL 32816, USA.

出版信息

Micromachines (Basel). 2022 Dec 21;14(1):14. doi: 10.3390/mi14010014.

DOI:10.3390/mi14010014
PMID:36677074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9864392/
Abstract

Plotter cutters in stencil mask prototyping are underutilized but have several advantages over traditional MEMS techniques. In this paper we investigate the use of a conventional plotter cutter as a highly effective benchtop tool for the rapid prototyping of stencil masks in the sub-250 μm range and characterize patterned layers of organic/inorganic materials. Furthermore, we show a new diagnostic monitoring application for use in healthcare, and a potential replacement of the Standard Kirby-Bauer Diffusion Antibiotic Resistance tests was developed and tested on both and as pathogens with Oxytetracycline, Streptomycin and Kanamycin. We show that the reduction in area required for the minimum inhibitory concentration tests; allow for three times the number of tests to be performed within the same nutrient agar Petri dish, demonstrated both theoretically and experimentally resulting in correlations of R ≈ 0.96 and 0.985, respectively for both pathogens.

摘要

在模板掩膜原型制作中，绘图切割机未得到充分利用，但与传统微机电系统技术相比具有若干优势。在本文中，我们研究了使用传统绘图切割机作为一种高效的台式工具，用于快速制作亚250μm范围内的模板掩膜，并对有机/无机材料的图案化层进行表征。此外，我们展示了一种用于医疗保健的新型诊断监测应用，并开发了一种潜在替代标准 Kirby-Bauer 扩散抗生素耐药性测试的方法，该方法在以土霉素、链霉素和卡那霉素作为病原体的 和 上进行了测试。我们表明，最低抑菌浓度测试所需面积的减少；使得在同一个营养琼脂培养皿中能够进行三倍数量的测试，理论和实验均证明，两种病原体的相关性分别约为R ≈ 0.96和0.985。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/4fc3cf5980e9/micromachines-14-00014-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/8781e24a43b1/micromachines-14-00014-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/6da7a71126df/micromachines-14-00014-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/f651d665d097/micromachines-14-00014-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/5d95fcce4f02/micromachines-14-00014-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/a1e1af39f538/micromachines-14-00014-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/7993acc00b0f/micromachines-14-00014-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/f4b2c74a9e57/micromachines-14-00014-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/c9960f40ac4e/micromachines-14-00014-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/6583f2ede256/micromachines-14-00014-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/f7d410d31d21/micromachines-14-00014-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/282eae759dfa/micromachines-14-00014-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/4fc3cf5980e9/micromachines-14-00014-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/8781e24a43b1/micromachines-14-00014-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/6da7a71126df/micromachines-14-00014-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/f651d665d097/micromachines-14-00014-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/5d95fcce4f02/micromachines-14-00014-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/a1e1af39f538/micromachines-14-00014-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/7993acc00b0f/micromachines-14-00014-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/f4b2c74a9e57/micromachines-14-00014-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/c9960f40ac4e/micromachines-14-00014-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/6583f2ede256/micromachines-14-00014-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/f7d410d31d21/micromachines-14-00014-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/282eae759dfa/micromachines-14-00014-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97e2/9864392/4fc3cf5980e9/micromachines-14-00014-g012.jpg

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