Brandolini Martina, Gatti Giulia, Grumiro Laura, Zannoli Silvia, Arfilli Valentina, Cricca Monica, Dirani Giorgio, Denicolò Agnese, Marino Maria Michela, Manera Martina, Mancini Andrea, Taddei Francesca, Semprini Simona, Sambri Vittorio
Unit of Microbiology, The Greater Romagna Area Hub Laboratory, 47522 Cesena, Italy.
Department of Experimental, Diagnostic and Specialty Medicine (DIMES)-Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy.
Microorganisms. 2023 Jan 12;11(1):191. doi: 10.3390/microorganisms11010191.
The recent emergence of a number of new SARS-CoV-2 variants resulting from recombination between two distinct parental lineages or sub-lineages within the same lineage has sparked the debate regarding potential enhanced viral infectivity and immune escape. Among these, XBB, recombinant of BA.2.10 and BA.2.75, has caused major concern in some countries due to its rapid increase in prevalence. In this study, we tested XBB escape capacity from mRNA-vaccine-induced (BNT162b2) neutralising antibodies compared to B.1 ancestral lineage and another co-circulating variant (B.1.1.529 BA.5) by analysing sera collected 30 days after the second dose in 92 healthcare workers. Our data highlighted an enhanced and statistically significant immune escape ability of the XBB recombinant. Although these are preliminary results, this study highlights the importance of immune escape monitoring of new and forthcoming variants and of the reformulation of existing vaccines.
最近出现了一些由两个不同亲本谱系或同一谱系内的亚谱系之间重组产生的新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体，这引发了关于潜在增强的病毒传染性和免疫逃逸的争论。其中，由BA.2.10和BA.2.75重组而成的XBB，因其流行率迅速上升，在一些国家引起了主要关注。在本研究中，我们通过分析92名医护人员在第二剂疫苗接种30天后采集的血清，测试了XBB相对于B.1祖先谱系和另一种共同流行的变体（B.1.1.529 BA.5）从mRNA疫苗诱导的（BNT162b2）中和抗体中的逃逸能力。我们的数据突出了XBB重组体增强的且具有统计学意义的免疫逃逸能力。尽管这些是初步结果，但本研究强调了对新出现和即将出现的变体进行免疫逃逸监测以及对现有疫苗进行重新配方的重要性。
