首次对 essential oil 和 extract of 进行植物化学成分分析及抗原生动物活性研究。
First Phytochemical Profiling and Antiprotozoal Activity of Essential Oil and Extract of .
机构信息
Université de Corse, UMR CNRS 6134 Sciences Pour l'Environnement, Laboratoire Chimie des Produits Naturels, BP 52, 20250 Corte, France.
UCLouvain, Louvain Drug Research Institute, Pharmacognosy Group, Avenue E. Mounier 72, B-1200 Brussels, Belgium.
出版信息
Molecules. 2023 Jan 7;28(2):616. doi: 10.3390/molecules28020616.
Volatiles metabolites from the liverwort harvested in Corsica were investigated by chromatographic and spectroscopic methods. In addition to already reported constituents, three new compounds were isolated by preparative chromatography and their structures were elucidated by mass spectrometry (MS) and NMR experiments. Hence, an atypic aliphatic compound, named 1,2-dihydro-4,5-dehydronerolidol and two isomers, (E) and (Z), possessing an unusual humbertiane skeleton (called -menth-1-en-3-[2-methylbut-1-enyl]-8-ol) are newly reported and fully characterized in this work. The in vitro antiprotozoal activity of essential oil and extract of against and and cytotoxicity were determined. Essential oil and EtO extract showed a moderate activity against with IC values: 2.03 and 5.18 μg/mL, respectively. It is noteworthy that only the essential oil showed a high selectivity (SI = 11.7). Diethyl oxide extract exhibited moderate anticancer (cancerous macrophage-like murine cells) activity and also cytotoxicity (human normal fibroblast) with IC values: 1.25 and 2.96 μg/mL, respectively.
采用色谱和光谱方法研究了从科西嘉采集的地钱中的挥发性代谢产物。除了已经报道的成分外，通过制备色谱分离出三种新化合物，并通过质谱（MS）和 NMR 实验阐明了它们的结构。因此，本文首次报道了一种非典型的脂肪族化合物，命名为 1,2-二氢-4,5-脱水橙皮醇，以及两种异构体（E）和（Z），它们具有不寻常的胡薄荷烷骨架（称为 - menth-1-en-3-[2-甲基丁烯基]-8-醇）。本文还对挥发油和提取物对 和 的体外抗原生动物活性和细胞毒性进行了测定。挥发油和 EtO 提取物对 表现出中等活性，IC 值分别为 2.03 和 5.18μg/mL。值得注意的是，只有挥发油表现出较高的选择性（SI = 11.7）。二氧乙烷提取物对癌细胞（鼠类巨噬细胞样癌细胞）具有中等抗癌活性，对人正常成纤维细胞也具有细胞毒性，IC 值分别为 1.25 和 2.96μg/mL。
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