Pampani Priyanka, Shenoy Santhosh, Punj Anahita, Kamath Vinayak B
Senior Lecturer, Department of Periodontics, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Tamil Nadu, India.
Additional Professor, Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, NITTE Deemed to be University, Deralakatte, Mangalore, Karnataka, India.
Contemp Clin Dent. 2021 Apr-Jun;12(2):157-163. doi: 10.4103/ccd.ccd_192_20. Epub 2021 Jun 14.
To investigate the total oxidant levels in healthy, chronic periodontitis (CP), and ischemic heart disease (IHD) and to check for any correlation among them.
A sample of 80 were split into four groups of healthy subjects (Group I), CP subjects (Group II), IHD subjects (Group III), and IHD subjects having periodontitis (Group IV). The serum and saliva samples collected were analyzed for levels of hydrogen peroxide (HO), hydroxyl radical (OH), nitric oxide (NO), and superoxide radical (O ).
There were significant ( < 0.05) variances in the mean serum and salivary levels of hydrogen peroxide, hydroxyl radical, NO, and superoxide within the 4 groups. Oxidant levels of both serum and saliva were lower in disease groups of Group II, III, and IV as compared to healthy controls, with different patterns.
The oxidant levels (HO, OH, NO, and O ) are significantly hampered in periodontitis and IHD subjects as compared to healthy subjects. The oxidants, whether serum or salivary, did not always show the proportional change as a result of change in oxidant stress due to disease as positive correlation was observed only in the serum HO and salivary NO radical levels and between serum superoxide dismutase radical and salivary HO in Group I. In Group III, there was a positive correlation between serum NO radical and salivary HO.
研究健康人群、慢性牙周炎（CP）患者和缺血性心脏病（IHD）患者的总氧化剂水平，并检查它们之间是否存在相关性。
将80名受试者分为四组，分别为健康受试者组（第一组）、CP患者组（第二组）、IHD患者组（第三组）和患有牙周炎的IHD患者组（第四组）。对采集的血清和唾液样本分析过氧化氢（HO）、羟基自由基（OH）、一氧化氮（NO）和超氧自由基（O ）的水平。
四组受试者血清和唾液中过氧化氢、羟基自由基、NO和超氧的平均水平存在显著差异（<0.05）。与健康对照组相比，第二组、第三组和第四组疾病组的血清和唾液氧化剂水平均较低，且模式不同。
与健康受试者相比，牙周炎和IHD患者的氧化剂水平（HO、OH、NO和O ）显著降低。无论是血清还是唾液中的氧化剂，并不总是因疾病导致的氧化应激变化而呈现比例变化，因为仅在第一组中观察到血清HO与唾液NO自由基水平之间以及血清超氧化物歧化酶自由基与唾液HO之间存在正相关。在第三组中，血清NO自由基与唾液HO之间存在正相关。
