Faculty of Animal Science and Biotechnology, University of Animal Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania.
Molecules. 2023 Jan 14;28(2):850. doi: 10.3390/molecules28020850.
Major progress has been made in cancer research; however, cancer remains one of the most important health-related burdens. Sericulture importance is no longer limited to the textile industry, but its by-products, such as silk fibroin or mulberry, exhibit great impact in the cancer research area. Fibroin, the pivotal compound that is found in silk, owns superior biocompatibility and biodegradability, representing one of the most important biomaterials. Numerous studies have reported its successful use as a drug delivery system, and it is currently used to develop three-dimensional tumor models that lead to a better understanding of cancer biology and play a great role in the development of novel antitumoral strategies. Moreover, sericin's cytotoxic effect on various tumoral cell lines has been reported, but also, it has been used as a nanocarrier for target therapeutic agents. On the other hand, mulberry compounds include various bioactive elements that are well known for their antitumoral activities, such as polyphenols or anthocyanins. In this review, the latest progress of using sericultural by-products in cancer therapy is discussed by highlighting their notable impact in developing novel effective drug strategies.
在癌症研究方面已经取得了重大进展；然而，癌症仍然是最重要的与健康相关的负担之一。蚕桑业的重要性不再局限于纺织行业，其副产品，如丝素或桑椹，在癌症研究领域也有重要影响。丝素是丝中发现的关键化合物，具有优异的生物相容性和可降解性，是最重要的生物材料之一。许多研究报告称其成功用作药物传递系统，目前用于开发三维肿瘤模型，有助于更好地了解癌症生物学，并在开发新型抗肿瘤策略方面发挥重要作用。此外，已经报道了丝胶对各种肿瘤细胞系的细胞毒性作用，并且还将其用作靶向治疗剂的纳米载体。另一方面，桑椹化合物包括各种生物活性元素，以其抗肿瘤活性而闻名，如多酚或花青素。在这篇综述中，通过强调其在开发新型有效药物策略方面的显著影响，讨论了蚕桑副产品在癌症治疗中的最新进展。
