Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Macromol Biosci. 2013 Aug;13(8):1020-35. doi: 10.1002/mabi.201300013. Epub 2013 Jun 3.
Mulberry silk fibroin is a widely used biomaterial and recent work on non-mulberry silk fibroin also suggests it may have similar uses. We expect silk fibroin from the only domesticated non-mulberry eri silkworm, Samia ricini, to possess useful properties as a biomaterial. Eri silk gland fibroin is a heterodimeric protein of approximately 450 kDa. Cytocompatibility evaluation with fibroblasts and osteoblast-like cells shows good cell attachment, viability and proliferation. The matrices, which have high thermal stability and good swellability, are also haemocompatible. Eri silk production is cost effective as no agronomic practices are required for their host plant cultivation. This fibroin provide new opportunities as an alternative natural functional biomaterial in various biomedical applications.
桑蚕丝素蛋白是一种广泛应用的生物材料，最近对非桑蚕丝素蛋白的研究也表明它可能具有类似的用途。我们预计，唯一驯化的国产非桑蚕——蓖麻蚕的丝素蛋白作为一种生物材料具有有用的特性。野蚕丝腺丝素蛋白是一种大约 450 kDa 的杂二聚体蛋白。与成纤维细胞和类成骨细胞的细胞相容性评估表明，其具有良好的细胞黏附性、活力和增殖性。该基质具有高热稳定性和良好的溶胀性，同时也具有良好的血液相容性。由于其宿主植物的栽培不需要农业措施，因此蓖麻蚕丝素蛋白的生产具有成本效益。这种丝素蛋白为各种生物医学应用提供了新的机会，可作为一种替代天然功能生物材料。
