载有亚硝基谷胱甘肽的纳米/微米制剂策略的简要综述
A Mini Review of -Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies.
作者信息
Ming Hui, Zhang Kunpeng, Ge Shengbo, Shi Yang, Du Chunan, Guo Xuqiang, Zhang Libo
机构信息
State Key Laboratory of Heavy Oil Processing, College of Engineering, China University of Petroleum-Beijing at Karamay, Karamay 834000, China.
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing 210037, China.
出版信息
Nanomaterials (Basel). 2023 Jan 4;13(2):224. doi: 10.3390/nano13020224.
As a potential therapeutic agent, the clinical application of -nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a physiological concentration in the active position. Due to the high water-solubility and small molecular-size of GSNO, the biggest challenges in the encapsulation step are low encapsulation efficiency and burst release. This review summarizes the different nano/micro-formulation strategies of a GSNO related delivery system to provide references for subsequent researchers interested in GSNO encapsulation.
作为一种潜在的治疗剂，亚硝基谷胱甘肽（GSNO）由于其不稳定性，临床应用受到限制。因此，人们开发了不同的制剂来保护GSNO不被降解，并使其在活性部位以生理浓度递送和释放。由于GSNO具有高水溶性和小分子尺寸，包封步骤中最大的挑战是包封效率低和突释。本综述总结了GSNO相关递送系统的不同纳米/微制剂策略，为后续对GSNO包封感兴趣的研究人员提供参考。
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