Saaranen M, Suistomaa U, Kantola M, Saarikoski S, Vanha-Perttula T
Department of Anatomy, University of Kuopio, Finland.
Hum Reprod. 1987 Aug;2(6):475-9. doi: 10.1093/oxfordjournals.humrep.a136573.
The concentrations of lead, magnesium, selenium and zinc in seminal fluid from men with variable semen quality (sperm morphology, density and motility) and fertility were determined by atomic absorption spectrometer without or with Zeeman background correction. The mean (+/- SD) concentration of selenium in the samples (n = 142) was 28.8 +/- 9.5 micrograms/l, which was about a third of the corresponding serum value (77.8 +/- 13.3 micrograms/l, n = 140). The serum selenium level was significantly (P less than 0.001) higher in infertile than in fertile men, but the seminal fluid did not show such a difference. No correlation was obtained between selenium values in seminal plasma and sperm density or motility. The levels of lead in seminal fluid were very low with no correlation to the levels of magnesium, selenium and zinc or the semen qualities. The seminal fluid lead concentration was significantly (P less than 0.001) higher in infertile (3.6 +/- 3.2 micrograms/l, n = 79) than in fertile men (1.7 +/- 1.0 micrograms/l, n = 39). Magnesium (103.5 +/- 49.2 mg/l, n = 90) and zinc (141.1 +/- 71.7 mg/l, n = 157) concentrations in seminal fluid were comparable with previous reports. Both minerals showed a positive correlation to the seminal fluid selenium, while only zinc displayed a borderline correlation with sperm density. The present findings indicate that the determination of seminal fluid selenium may not offer any advantages over zinc and magnesium measurement in the fertility assessment and its role in human semen remains obscure. The low lead concentrations in the present material is a clear indication of low industrial exposure.
采用原子吸收光谱仪，在有无塞曼背景校正的情况下，测定了精液质量（精子形态、密度和活力）及生育能力各异的男性精液中铅、镁、硒和锌的浓度。样本（n = 142）中硒的平均（±标准差）浓度为28.8±9.5微克/升，约为相应血清值（77.8±13.3微克/升，n = 140）的三分之一。不育男性的血清硒水平显著高于生育男性（P < 0.001），但精液中未显示出这种差异。精浆中的硒值与精子密度或活力之间未发现相关性。精液中的铅含量非常低，与镁、硒和锌的含量或精液质量均无相关性。不育男性（3.6±3.2微克/升，n = 79）精液中的铅浓度显著高于生育男性（1.7±1.0微克/升，n = 39）（P < 0.001）。精液中镁（103.5±49.2毫克/升，n = 90）和锌（141.1±71.7毫克/升，n = 157）的浓度与先前报道相当。这两种矿物质均与精液中的硒呈正相关，而只有锌与精子密度呈临界相关性。目前的研究结果表明，在生育能力评估中，测定精液中的硒可能并不比测定锌和镁更具优势，其在人类精液中的作用仍不明确。本研究材料中铅浓度较低，明确表明工业暴露水平较低。
