Boragno Paola, Fiabane Elena, Colledani Daiana, Dalla Gasperina Daniela, Setti Ilaria, Sommovigo Valentina, Gabanelli Paola
Istituti Clinici Scientifici Maugeri IRCCS, Psychology Unit of Pavia Institute, 27100 Pavia, Italy.
Istituti Clinici Scientifici Maugeri IRCCS, Department of Physical and Rehabilitation Medicine of Genova Nervi Institute, 16121 Genova, Italy.
Vaccines (Basel). 2023 Jan 7;11(1):138. doi: 10.3390/vaccines11010138.
Little is known about the use of intranasal vaccines, but some studies have shown that this innovative way of administration is preferred over needle injection as it is considered both less painful and intrusive to the body, equally effective, and associated with fewer side effects. This study aimed to investigate specific psychological determinants (intolerance of uncertainty, persecutory ideation, perceived control, vaccine hesitancy) of attitude toward nasal vaccine delivery. A convenience sample including 700 Italian participants took part in this cross-sectional study and completed an online questionnaire. A structural equation model with a latent variable was performed to study the relationship between psychological variables, vaccine hesitancy, and attitude toward nasal vaccine delivery. The results indicate that both a hesitant attitude toward vaccination ( = 0.20, = 0.000) and low perceived control ( = -0.20, = 0.005) may directly increase preference for nasal administration; furthermore, high levels of persecutory ideation may indirectly influence the propensity for intranasal vaccine. These findings suggest that pharmaceutical companies could implement nasal vaccines and provide detailed information on these vaccines through informational campaigns. Hesitant individuals with low levels of perceived control could more easily comply with these types of vaccines.
关于鼻内疫苗的使用，人们了解得并不多，但一些研究表明，这种创新的给药方式比注射更受青睐，因为它被认为疼痛较轻且对身体的侵入性较小，效果相同，且副作用较少。本研究旨在调查对鼻内疫苗接种态度的特定心理决定因素（对不确定性的不耐受、迫害观念、感知控制、疫苗犹豫）。一个包括700名意大利参与者的便利样本参与了这项横断面研究，并完成了一份在线问卷。采用带有潜在变量的结构方程模型来研究心理变量、疫苗犹豫和对鼻内疫苗接种态度之间的关系。结果表明，对疫苗接种的犹豫态度（β = 0.20，p = 0.000）和低感知控制（β = -0.20，p = 0.005）都可能直接增加对鼻内给药的偏好；此外，高水平的迫害观念可能间接影响鼻内疫苗的倾向。这些发现表明，制药公司可以推广鼻内疫苗，并通过宣传活动提供有关这些疫苗的详细信息。感知控制水平较低的犹豫个体可能更容易接受这类疫苗。
