Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, The Russian Academy of Sciences, 117997 Moscow, Russia.
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Viruses. 2023 Jan 14;15(1):241. doi: 10.3390/v15010241.
ADP-ribosylation (ADPRylation) is a versatile posttranslational modification in eukaryotic cells which is involved in the regulation of a wide range of key biological processes, including DNA repair, cell signalling, programmed cell death, growth and development and responses to biotic and abiotic stresses. Members of the poly(ADP-ribosyl) polymerase (PARP) family play a central role in the process of ADPRylation. Protein targets can be modified by adding either a single ADP-ribose moiety (mono(ADP-ribosyl)ation; MARylation), which is catalysed by mono(ADP-ribosyl) transferases (MARTs or PARP "monoenzymes"), or targets may be decorated with chains of multiple ADP-ribose moieties (PARylation), via the activities of PARP "polyenzymes". Studies have revealed crosstalk between PARylation (and to a lesser extent, MARylation) processes in plants and plant-virus interactions, suggesting that these tight links may represent a novel factor regulating plant antiviral immunity. From this perspective, we go through the literature linking PARylation-associated processes with other plant regulation pathways controlling virus resistance. Once unraveled, these links may serve as the basis of innovative strategies to improve crop resistance to viruses under challenging environmental conditions which could mitigate yield losses.
ADP-核糖基化 (ADPRylation) 是真核细胞中一种多功能的翻译后修饰，参与调节广泛的关键生物学过程，包括 DNA 修复、细胞信号转导、程序性细胞死亡、生长发育以及对生物和非生物胁迫的反应。多聚 ADP-核糖聚合酶 (PARP) 家族成员在 ADPRylation 过程中发挥核心作用。蛋白靶标可以通过添加单个 ADP-核糖基单元（单 ADP-核糖基化；MARylation）进行修饰，这是由单 ADP-核糖基转移酶（MART 或 PARP“单酶”）催化的，或者靶标可以通过 PARP“多酶”的活性被多个 ADP-核糖基单元的链修饰（PARylation）。研究揭示了植物中 PARylation（和较少程度的 MARylation）过程与植物-病毒相互作用之间的串扰，表明这些紧密联系可能代表一种新的调节植物抗病毒免疫的因素。从这个角度来看，我们查阅了将 PARylation 相关过程与控制病毒抗性的其他植物调节途径联系起来的文献。一旦揭示这些联系，它们可能成为在具有挑战性的环境条件下提高作物对病毒抗性的创新策略的基础，从而减轻产量损失。
