Thiede A, Timm C, Bernhard A, Müller-Ruchholtz W
Transplantation. 1978 Dec;26(6):391-5. doi: 10.1097/00007890-197812000-00005.
The use of defined inbred strains of rats enables reproducible experimentation on the antigenicity of heart valve leaflet transplantation. The inbred strains CAP, F344, and LEW were used as syngeneic, weakly allogeneic (RT-1-identical) and strongly allogeneic (RT-1-incompatible) strain combinations. After heart valve leaflet transplantation, humoral and cell-mediated immune responses were investigated. The results were: (1) Allogeneic heart valve leaflets are antigenic. (2) Just one heart valve leaflet, applied intravascularly induces sensitization of the recipient. (3) In the weakly allogeneic system, sensitization is only revealed by donor-specific skin transplants, while in the strongly allogeneic group, sensitization is demonstrated humorally as well. (4) The greater the immunogenetical difference, the sooner sensitization appears. In the strongly allogeneic system, skin transplants were rejected as "white grafts".
使用特定的近交系大鼠能够对心脏瓣膜小叶移植的抗原性进行可重复的实验。近交系CAP、F344和LEW被用作同基因、弱异基因（RT-1相同）和强异基因（RT-1不兼容）的品系组合。在心脏瓣膜小叶移植后，研究了体液免疫和细胞介导的免疫反应。结果如下：（1）异基因心脏瓣膜小叶具有抗原性。（2）仅一个经血管应用的心脏瓣膜小叶就能诱导受体致敏。（3）在弱异基因系统中，仅通过供体特异性皮肤移植才能显示致敏，而在强异基因组中，体液致敏也得到证实。（4）免疫遗传学差异越大，致敏出现得越早。在强异基因系统中，皮肤移植作为“白色移植物”被排斥。
