School of Public Health, Medical College of Soochow University, Suzhou, China.
Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
Eye (Lond). 2023 Sep;37(13):2707-2715. doi: 10.1038/s41433-023-02403-4. Epub 2023 Jan 23.
To assess the relationship between sleep duration and the risk of major eye disorders including myopia, glaucoma, cataract, age-related macular degeneration (AMD), and diabetic retinopathy (DR).
Databases including PubMed, Embase, Web of Science, and Cochrane library were searched for eligible publications before July 2021. Studies assessing the relationship between sleep duration and any one of the major eye disorders were identified. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were estimated using random-effects models.
We identified 21 relevant articles including 777348 participants, and 17 were cross-sectional, 3 were longitudinal, and 1 was case-control. Pooled results indicated that long sleep duration was significantly associated with the risk of DR (OR = 1.84, 95% CI 1.24, 2.73), and short sleep duration was significantly associated with the risk of cataract (OR = 1.20, 95% CI 1.05, 1.36). Besides, a significant relationship was observed between the risk of DR and long sleep duration per day (i.e., nighttime sleep plus daytime napping, OR = 1.74, 95% CI 1.23, 2.44) rather than per night (OR = 2.17, 95% CI 0.95, 4.99). The extreme of long sleep duration (i.e., >10 h per night) increased the risk of myopia (OR = 1.02, 95% CI 1.01, 1.04).
Inappropriate sleep duration might increase the risk of major eye disorders. The findings could contribute to the growing knowledge on the possible relationship between circadian rhythms and eye disorders.
评估睡眠时长与主要眼部疾病（包括近视、青光眼、白内障、年龄相关性黄斑变性（AMD）和糖尿病性视网膜病变（DR））风险之间的关系。
检索了 PubMed、Embase、Web of Science 和 Cochrane 图书馆等数据库，以获取截至 2021 年 7 月之前的相关文献。纳入评估睡眠时长与任何一种主要眼部疾病之间关系的研究。采用随机效应模型估计汇总优势比（OR）及其相应的 95%置信区间（95%CI）。
共纳入 21 项相关研究，包含 777348 名参与者，其中 17 项为横断面研究，3 项为纵向研究，1 项为病例对照研究。汇总结果表明，长睡眠时长与 DR 风险显著相关（OR=1.84，95%CI 1.24，2.73），短睡眠时长与白内障风险显著相关（OR=1.20，95%CI 1.05，1.36）。此外，每天长睡眠时长（即夜间睡眠加日间小睡，OR=1.74，95%CI 1.23，2.44）与 DR 风险之间存在显著关系，而每晚睡眠时间（OR=2.17，95%CI 0.95，4.99）与 DR 风险之间无显著关系。长睡眠时长的极端情况（即每晚>10 小时）增加了近视的风险（OR=1.02，95%CI 1.01，1.04）。
不适当的睡眠时长可能会增加主要眼部疾病的风险。这些发现有助于增加对昼夜节律与眼部疾病之间可能关系的认识。
