Department of Ophthalmology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, China.
Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, China.
Sci Rep. 2024 Jun 7;14(1):13101. doi: 10.1038/s41598-024-63973-1.
Currently, a comprehensive assessment of the relationship between ideal cardiovascular health (CVH) indicators and cataract risk is lacking. Life's Essential 8 (LE8) is the latest concept proposed by the American Heart Association to comprehensively reflect CVH status. LE8 includes four health behaviors (diet, physical activity, smoking, and sleep) and four health factors (blood lipid, blood sugar, blood pressure, and body mass index). This study tried to evaluate the association between LE8 and cataract using data from National Health and Nutrition Examination Survey (NHANES) 2005-2008, a continuous research program which aims to monitor and evaluate the health and nutrition status of the US population. A cross-sectional study of 2720 non-cataract participants and 602 cataract participants. All participants were assigned to the poor, intermediate, and ideal CVH status groups based on LE8 score. Weighted multiple logistic regression was used to investigate the correlation between the LE8 score and cataract, as well as the correlation between each of the eight subitems and cataract, with potential confounding variables being adjusted. Then, restricted cubic spline analysis was used to further explore whether there was a nonlinear relationship between LE8 score and cataract. The proportion of cataract participants was 14.1%, 18.2%, and 20.6% in the ideal, intermediate, and poor CVH groups, respectively (P < 0.05). LE8 score was inversely associated with cataract risk, with each 10-point increase in LE8 score associated with a 14% reduction in cataract risk [odds ratio (OR) = 0.86, 95% confidence interval (CI): 0.79-0.93, P < 0.01]. Among all the LE8 subitems, physical activity, sleep, and blood glucose were significantly associated with cataract risk (all P < 0.05). Better CVH, defined by a higher LE8 score, is associated with a lower cataract risk. Efforts to improve LE8 score (especially when it comes to physical activity, sleep, and blood glucose) may serve as a novel strategy to help reduce the risk of cataract.
目前，缺乏对理想心血管健康（CVH）指标与白内障风险之间关系的综合评估。Life's essential 8（LE8）是美国心脏协会提出的最新概念，用于全面反映 CVH 状况。LE8 包括四项健康行为（饮食、身体活动、吸烟和睡眠）和四项健康因素（血脂、血糖、血压和体重指数）。本研究试图利用 2005-2008 年国家健康和营养调查（NHANES）的数据评估 LE8 与白内障之间的关系，该研究计划旨在监测和评估美国人口的健康和营养状况。这是一项针对 2720 名非白内障参与者和 602 名白内障参与者的横断面研究。根据 LE8 评分，所有参与者被分为差、中、理想 CVH 状态组。使用加权多因素逻辑回归分析 LE8 评分与白内障之间的相关性，以及八项亚项与白内障之间的相关性，并调整潜在混杂因素。然后，使用限制三次样条分析进一步探讨 LE8 评分与白内障之间是否存在非线性关系。在理想、中等和差 CVH 组中，白内障参与者的比例分别为 14.1%、18.2%和 20.6%（P<0.05）。LE8 评分与白内障风险呈负相关，LE8 评分每增加 10 分，白内障风险降低 14%[比值比（OR）=0.86，95%置信区间（CI）：0.79-0.93，P<0.01]。在所有 LE8 亚项中，身体活动、睡眠和血糖与白内障风险显著相关（均 P<0.05）。更好的 CVH，定义为更高的 LE8 评分，与较低的白内障风险相关。努力提高 LE8 评分（尤其是在身体活动、睡眠和血糖方面）可能是降低白内障风险的一种新策略。
