Xinyang Vocational and Technical College, Xinyang Henan, 464000, China.
Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Anticancer Agents Med Chem. 2023;23(9):999-1012. doi: 10.2174/1871520623666230120094158.
Cancer drug resistance has always been a serious issue regarding cancer research and therapy. Different cancers undergo different mutations, which may cause suppression of tumor suppressor genes, inhibition of apoptosis, stimulation of drug resistance mediators, and exhaustion of the immune system. The modulation of pro-death and survival-related mediators is an intriguing strategy for cancer therapy. Several nature-derived molecules, e.g., quercetin, have shown interesting properties against cancer through the modulation of apoptosis and autophagy mediators. Such molecules, e.g., quercetin, have been shown to stimulate apoptosis and other types of cell death pathways in cancers via the modulation of ROS metabolism. Quercetin may affect immune system function and trigger the expression and activity of tumor suppressor genes. Furthermore, it may suppress certain multidrug resistance mechanisms in cancer cells. This paper aims to review the effects of quercetin on various cell death mechanisms such as apoptosis, autophagic cell death, senescence, ferroptosis, and others.
癌症耐药性一直是癌症研究和治疗中的一个严重问题。不同的癌症会经历不同的突变，这可能导致肿瘤抑制基因的抑制、细胞凋亡的抑制、耐药介质的刺激和免疫系统的衰竭。促死亡和存活相关介质的调节是癌症治疗的一个有趣策略。几种天然来源的分子，如槲皮素，通过调节细胞凋亡和自噬介质显示出对癌症的有趣特性。例如，槲皮素通过调节 ROS 代谢来刺激癌症中的细胞凋亡和其他类型的细胞死亡途径。槲皮素可能影响免疫系统功能并触发肿瘤抑制基因的表达和活性。此外，它可能抑制癌细胞中的某些多药耐药机制。本文旨在综述槲皮素对各种细胞死亡机制的影响，如细胞凋亡、自噬性细胞死亡、衰老、铁死亡等。
