Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, China.
Front Immunol. 2023 Jan 5;13:1071219. doi: 10.3389/fimmu.2022.1071219. eCollection 2022.
Anti-leucine-rich glioma inactivated 1(LGI1) encephalitis is one rare autoimmune encephalitis which is accompanied by inflammatory responses. (Anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis is an autoimmune disease mediated by inflammatory responses.)This study aimed to investigate the Chitinase 3-like 1(CHI3L1) in anti-LGI1encephalitis patients and evaluate its association with modified Rankin Scale (mRS) score in anti-LGI1 encephalitis at admission and 6 months follow-up.(This study looked into the relationship between Chitinase 3-like 1 (CHI3L1) and the modified Ranking Scale (mRS) score in anti-LGI1 encephalitis patients at admission and 6 months later.).
Thirty-five patients with anti-LGI1 encephalitis and 22 patients with non-inflammatory neurological disease were enrolled in this study. (We enrolled 35 patients with anti-LGI1 encephalitis and 22 patients with non-inflammatory neurological disease.)Cerebrospinal fluid (CSF) and serum levels of CHI3L1 were measured by enzyme-linked immunosorbent assay. (We quantified CHI3L1 in the serum and cerebrospinal fluid (CSF) by performing an enzyme-linked immunosorbent assay.)Patients were evaluated for mRS score at admission and at 6 months follow-up.(We recorded the mRS score of the patients at admission and 6 months later.).
CHI3L1 levels in CSF and serum were highly elevated in patients with anti-LGI1 encephalitis at admission compared those with the controls.(At admission, patients with anti-LGI1 encephalitis had elevated CHI3L1 levels in the CSF and serum.) Additionally, patients presenting with cognitive impairment had significantly higher CSF CHI3L1 levels and mRS scores than those without cognitive impairment symptoms. Patients presenting with only faciobrachial dystonic seizures at admission had lower CSF CHI3L1 levels than those with other symptoms. Finally, CSF CHI3L1 levels were positively correlated with CSF lactate levels.
CHI3L1 level in CSF is correlated with the severity and prognosis of anti-LGI1 encephalitis. (CSF CHI3L1 levels are correlated with the severity and prognosis of anti-LGI1 encephalitis.).
抗富亮氨酸胶质瘤失活 1 型（LGI1）脑炎是一种罕见的自身免疫性脑炎，伴有炎症反应。（抗富亮氨酸胶质瘤失活 1 型（抗 LGI1）脑炎是一种由炎症反应介导的自身免疫性疾病。）本研究旨在探讨抗 LGI1 脑炎患者中的几丁质酶 3 样 1（CHI3L1），并评估其与入院时和 6 个月随访时改良 Rankin 量表（mRS）评分的相关性。（本研究探讨了抗 LGI1 脑炎患者入院时和 6 个月后 CHI3L1 与改良 Rankin 量表（mRS）评分的关系。）
本研究纳入了 35 例抗 LGI1 脑炎患者和 22 例非炎症性神经疾病患者。（我们纳入了 35 例抗 LGI1 脑炎患者和 22 例非炎症性神经疾病患者。）通过酶联免疫吸附试验测量脑脊液（CSF）和血清中 CHI3L1 的水平。（我们通过酶联免疫吸附试验在血清和脑脊液（CSF）中定量 CHI3L1。）患者在入院时和 6 个月随访时进行 mRS 评分评估。（我们记录了患者入院时和 6 个月后的 mRS 评分。）
与对照组相比，入院时抗 LGI1 脑炎患者的 CSF 和血清中 CHI3L1 水平显著升高。（入院时，抗 LGI1 脑炎患者的 CSF 和血清中 CHI3L1 水平升高。）此外，伴有认知障碍的患者 CSF CHI3L1 水平和 mRS 评分明显高于无认知障碍症状的患者。入院时仅表现为面臂肌张力障碍发作的患者 CSF CHI3L1 水平低于其他症状患者。最后，CSF CHI3L1 水平与 CSF 乳酸水平呈正相关。
CSF 中 CHI3L1 水平与抗 LGI1 脑炎的严重程度和预后相关。（CSF CHI3L1 水平与抗 LGI1 脑炎的严重程度和预后相关。）
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