Howard R S, Russell R W
Department of Neurology, St Thomas' Hospital, London, UK.
J Neurol Neurosurg Psychiatry. 1987 Sep;50(9):1142-7. doi: 10.1136/jnnp.50.9.1142.
Eighty-five patients with retinal emboli, visible ophthalmoscopically, were studied retrospectively. All the patients had presented with transient or permanent visual loss. Follow up from the time of presentation was one year to 12 years with a mean of 4.5 years. Life expectancy in the 58 medically treated patients who presented with cholesterol emboli was significantly reduced (p = 0.028). Stroke was the commonest cause of death and was significantly more frequent than in the general population (p less than 0.001); there was also an increased total incidence of cerebrovascular disease (fatal and non-fatal) compared with the Oxfordshire Stroke Project (p less than 0.001). The mortality from ischaemic heart disease was not significantly increased. We report a series of 85 patients with retinal emboli, 69 of whom had cholesterol emboli (70 fundi), 15 calcific emboli and one platelet-fibrin embolus. The natural history of medically treated patients with cholesterol emboli is compared both with an age and sex matched population and with patients with amaurosis fugax but no visible retinal emboli.
对85例经检眼镜可见视网膜栓子的患者进行了回顾性研究。所有患者均有过短暂或永久性视力丧失。从发病时起随访1年至12年，平均4.5年。58例出现胆固醇栓子且接受药物治疗的患者预期寿命显著缩短（p = 0.028）。中风是最常见的死亡原因，且比一般人群更为频繁（p < 0.001）；与牛津郡中风项目相比，脑血管疾病（致命和非致命）的总发病率也有所增加（p < 0.001）。缺血性心脏病的死亡率没有显著增加。我们报告了一系列85例视网膜栓子患者，其中69例有胆固醇栓子（70只眼），15例有钙化栓子，1例有血小板纤维蛋白栓子。将接受药物治疗的胆固醇栓子患者的自然病史与年龄和性别匹配的人群以及有一过性黑矇但无可见视网膜栓子的患者进行了比较。
