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Rigidity and dorsiflexion of the neck in progressive supranuclear palsy and the interstitial nucleus of Cajal.

作者信息

Fukushima-Kudo J, Fukushima K, Tashiro K

机构信息

Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan.

出版信息

J Neurol Neurosurg Psychiatry. 1987 Sep;50(9):1197-203. doi: 10.1136/jnnp.50.9.1197.

DOI:10.1136/jnnp.50.9.1197
PMID:3668569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1032355/
Abstract

Rigidity and dorsiflexion of the neck are typical signs in progressive supranuclear palsy, but the responsible areas in the brain are unknown. To examine whether bilateral lesions of the interstitial nucleus of Cajal (INC) in the midbrain tegmentum contribute to the signs of patients with progressive supranuclear palsy, we have made bilateral INC lesions in cats and tried to correlate these studies with clinical and pathological data, including our case of progressive supranuclear palsy. Bilateral INC lesioned cats showed dorsiflexion of the neck and impairment of vertical eye movement, similar to progressive supranuclear palsy patients. Analysis of the previous clinical-pathological studies and our case have shown that dorsiflexion of the neck in progressive supranuclear palsy patients was correlated more with INC lesions than lesions of the basal ganglia.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a1e/1032355/3140a54ae826/jnnpsyc00556-0100-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a1e/1032355/f12ca62360fa/jnnpsyc00556-0099-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a1e/1032355/d2e90e275f77/jnnpsyc00556-0099-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a1e/1032355/3140a54ae826/jnnpsyc00556-0100-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a1e/1032355/f12ca62360fa/jnnpsyc00556-0099-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a1e/1032355/d2e90e275f77/jnnpsyc00556-0099-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a1e/1032355/3140a54ae826/jnnpsyc00556-0100-a.jpg

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本文引用的文献

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PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA.进行性核上性麻痹。一种涉及脑干、基底神经节和小脑的异质性变性，伴有垂直凝视和假性延髓麻痹、颈部肌张力障碍和痴呆。
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Vertical eye movement-related responses of neurons in midbrain near intestinal nucleus of Cajal.
与持续性颈部伸展相关的背侧中脑综合征：2只犬的临床和诊断性影像学表现
Can Vet J. 2015 Dec;56(12):1261-5.
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Dystonia in progressive supranuclear palsy.进行性核上性麻痹中的肌张力障碍
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7
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Exp Brain Res. 1990;79(1):43-64. doi: 10.1007/BF00228872.
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Exp Brain Res. 1990;79(1):25-42. doi: 10.1007/BF00228871.
9
Activity of eye movement-related neurons in and near the interstitial nucleus of Cajal during sinusoidal vertical linear acceleration and optokinetic stimuli.在正弦垂直线性加速度和视动刺激期间， Cajal间质核及其附近与眼球运动相关的神经元的活动。
Exp Brain Res. 1991;85(1):45-54. doi: 10.1007/BF00229985.
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Vertical glaze paralysis and the rostral interstitial nucleus of the medial longitudinal fasciculus.垂直性凝视麻痹与内侧纵束的嘴侧间质核
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