Multi-functional gene ZNF281 identified as a molecular biomarker in soft tissue regeneration and pan-cancer progression.

Regeneration and tumorigenesis are indicated as related processes, while regeneration leads to life and the outcome of tumorigenesis is death. Here, we show the upregulation of (zinc finger 281) in our adipose regeneration model through RNA-seq analysis. Then, we validated the upregulation of zfp281 in adipose regeneration immunofluorescence. Following that, we found that (the human homolog of ) was upregulated in most types of cancer and related to worse prognosis in 10 tumors. We further investigated the role of in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), pancreatic adenocarcinoma (PAAD), and stomach adenocarcinoma (STAD) and confirmed the high accuracy in the clinical diagnostic feature. Beyond that, based on these three types of cancers, we analyzed the -related tumor immune infiltration and DNA methylation sites and finally built risk prediction models for future disease diagnosis. Taken together, our findings provide new insights into the dual role of , and we found that it was a potential biomarker for regeneration and tumor prognosis.