山楂原花青素低聚物提取物介导HCT116细胞的细胞周期阻滞、凋亡和溶酶体空泡化。

Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells.

作者信息

Sun Ya-Sai, Wang Zi-Wei, Gao Zhe, Zhao Wen, Thakur Kiran, Zhong Qian, Wei Zhao-Jun

机构信息

College of Food Science and Technology, Agricultural University of Hebei, Baoding, 071001, PR China.

School of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, PR China.

出版信息

Curr Res Food Sci. 2022 May 29;5:904-917. doi: 10.1016/j.crfs.2022.05.009. eCollection 2022.

In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) and death receptor (Caspase 8-Caspase 3) pathways. Meanwhile, it was found that HPOE aggravated HCT116 cells death through lysosomal vacuolation, which was verified by inhibitor/activator of P53-ILC3 signaling pathway. Taken together, HPOE exerted anticancer effects which lays the foundation for the development of functional foods for clinical colon cancer patients.