Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan, China.
Department of Public Health, School of Public Health, Wuhan University, Wuhan, China.
Int J Public Health. 2023 Jan 5;67:1605391. doi: 10.3389/ijph.2022.1605391. eCollection 2022.
To investigate the effect of exposure to multiple ambient air pollutants during pregnancy on the risk of children being born small for gestational age (SGA). An Air Pollution Score (APS) was constructed to assess the effects of being exposed to six air pollutants simultaneously, PM, PM, SO, NO, CO, and O (referred to as joint exposure). A logistic regression model was applied to estimate the associations of APS and SGA. The adjusted odds ratios (ORs) of SGA per 10 ug/m increased in APS during the first and second trimesters and the entire pregnancy were 1.003 [95% confidence intervals (CIs): 1.000, 1.007], 1.018 (1.012, 1.025), and 1.020 (1.009, 1.031), respectively. The ORs of SGA for each 10 μg/m elevated in APS during the whole pregnancy were 1.025 (1.005, 1.046) for mothers aged over 35 years old vs. 1.018 (1.005, 1.031) for mothers aged under 35 years old. Women who were pregnant for the first time were more vulnerable to joint ambient air pollution. In summary, the results of the present study suggested that joint exposure to ambient air pollutants was associated with the increment in the risks of SGA.
探讨孕期暴露于多种环境空气污染物对小于胎龄儿（SGA）发生风险的影响。构建空气污染评分（APS）来评估同时暴露于六种空气污染物（PM、PM、SO、NO、CO 和 O）的影响（简称联合暴露）。应用逻辑回归模型估计 APS 与 SGA 的关联。
在整个孕期，APS 每增加 10μg/m，SGA 的调整后比值比（OR）分别为 1.003（95%置信区间：1.000，1.007）、1.018（1.012，1.025）和 1.020（1.009，1.031）。APS 每增加 10μg/m，高龄（>35 岁）孕妇 SGA 的 OR 为 1.025（1.005，1.046），而低龄（<35 岁）孕妇的 OR 为 1.018（1.005，1.031）。初次妊娠的女性对联合环境空气污染更为敏感。
本研究结果表明，联合暴露于环境空气污染物与 SGA 风险增加有关。
