Li Zhiyu, Zhao Pu, Xu Qing, Bi Jianhai, Huo Ran
Department of Plastic and Aesthetic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, People's Republic of China.
Department of Plastic Surgery, Liaocheng Hospital of Traditional Chinese Medicine, Liaocheng, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Jan 14;16:99-102. doi: 10.2147/CCID.S394141. eCollection 2023.
The incidence of adverse events after hyaluronic acid filling is gradually increasing. In addition to acute reactions in the early postoperative period, there have been some cases of delayed inflammatory reactions. However, such events are rarely reported in Asia, which may be due to atypical symptoms, long intervals, and misidentification of the product quality. Herein, we present a case in which erythema of the neck appeared three weeks after hyaluronic acid injection into the neck lines and a delayed inflammatory reaction was diagnosed. Watchful waiting was performed, and the erythema subsided spontaneously after two weeks. This case suggests that in patients with a history of hyaluronic acid injections who develop allergic and inflammatory reactions after an interval, it is important to consider whether the reaction is a delayed inflammatory reaction, and if aggressive intervention is necessary.
透明质酸填充后不良事件的发生率正在逐渐上升。除了术后早期的急性反应外，还出现了一些迟发性炎症反应的病例。然而，此类事件在亚洲鲜有报道，这可能是由于症状不典型、间隔时间长以及对产品质量的误判所致。在此，我们报告一例在颈部皱纹注射透明质酸三周后出现颈部红斑并被诊断为迟发性炎症反应的病例。我们采取了观察等待的策略，两周后红斑自行消退。该病例提示，有透明质酸注射史的患者在间隔一段时间后出现过敏和炎症反应时，重要的是要考虑该反应是否为迟发性炎症反应，以及是否需要积极干预。
